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The safety and warning information for Syndros (dronabinol) is crucial for ensuring its safe use. Please review the following points carefully and discuss any concerns with your healthcare provider:

• Mental Health Side Effects: Individuals with mental health conditions such as mania, depression, or schizophrenia may experience exacerbated symptoms while on Syndros. Inform your healthcare provider if you have a history of such conditions. They may adjust your dosage or consider alternative treatments. Those at higher risk include older adults, individuals with a history of mental health issues, those taking other sedative medications, or consuming alcohol.

• Seizure Risk: Syndros may increase the likelihood of seizures. If you have a history of seizures, confer with your prescriber to assess if this medication is appropriate for you. Discontinue use and seek immediate medical attention if a seizure occurs.

• Cardiovascular Effects: This medication can affect blood pressure and heart rate, potentially causing faintness. Individuals with a history of cardiovascular issues or those taking other heart-affecting medications should be particularly cautious. Consult your healthcare provider if you are taking stimulants or tricyclic antidepressants.

• Potential for Misuse or Dependence: As a schedule II controlled substance, Syndros poses a risk of misuse and dependence. If you have a history of substance or alcohol misuse, discuss this with your healthcare provider to evaluate the risks and benefits. Alternative treatments may be considered.

• Gastrointestinal Effects: In rare cases, Syndros may exacerbate nausea, vomiting, or stomach pain. Notify your prescriber if your symptoms worsen, as a dose adjustment or discontinuation may be necessary.

• Serious Drug Interactions: Avoid taking Syndros with disulfiram or metronidazole, or within two weeks of these medications, due to the risk of a disulfiram-like reaction. This can cause symptoms such as nausea, vomiting, and flushing. Consult your healthcare provider to review your medications for possible interactions.

Contraindications: Do not use Syndros if you have an allergy to alcohol or are currently taking, or have recently taken, medications that interact with alcohol, such as metronidazole or disulfiram. Discuss any of these conditions with your healthcare provider before starting this medication.

When taking this medication, some people may experience common side effects such as dizziness, lightheadedness, and drowsiness, which are generally mild and improve as your body adjusts. Feeling euphoric or having an exaggerated sense of well-being, along with nausea, vomiting, and stomach pain, may also occur. If these mild effects persist or worsen, it's advisable to consult your healthcare provider.

Additionally, some individuals might experience more concerning symptoms, such as confusion, weakness, poor coordination, or memory loss. Mental and mood changes like anxiety, nervousness, paranoia, abnormal thoughts, or hallucinations have also been reported. If you encounter fast or pounding heartbeats, or any of these symptoms, it is important to seek medical advice promptly.

Serious side effects, though rare, include seizures and worsening mental health conditions, such as depression, mania, or schizophrenia. A severe allergic reaction is also possible, presenting with rash, itching or swelling, severe dizziness, or trouble breathing. Immediate medical attention is crucial if any of these occur. Remember, while these side effects can be alarming, they are uncommon, and many people use this medication without serious complications.

Dronabinol solution contains alcohol, which can interact with certain medications like disulfiram and metronidazole. You should avoid taking these medications within 2 weeks before, during, or up to 7 days after using dronabinol solution, as this combination can trigger reactions such as flushing, throbbing headache, difficulty breathing, nausea, vomiting, dizziness, severe fatigue, fainting, rapid or irregular heartbeat, or blurred vision. It is important to discuss these potential interactions with your doctor or pharmacist.

Additionally, inform your healthcare provider if you are using other substances that may cause drowsiness. These include opioid pain medications or cough suppressants (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or antihistamines (e.g., cetirizine, diphenhydramine). Be sure to check all your medications, including those for allergies or cold symptoms, as they might contain ingredients that cause drowsiness. Consult your pharmacist to ensure safe use of these products.