HomeDrug ClassesAldosterone Antagonist / Thiazide Diuretic Combinations

Aldosterone Antagonist / Thiazide Diuretic Combinations: Uses, Common Brands, and Safety Info

Aldosterone antagonist/thiazide diuretic combinations are medications used to treat high blood pressure. They lower blood pressure by reducing water and salt in the body. Common brands include Dyazide and Aldactazide. While generally safe, side effects may include dizziness and electrolyte imbalances. These medications are not recommended during pregnancy or breastfeeding.


Aldosterone antagonist/thiazide diuretic combinations are a class of medications that are used to treat high blood pressure (hypertension). These medications combine two different types of drugs: aldosterone antagonists and thiazide diuretics. This combination helps to lower blood pressure by reducing the amount of water and salt in the body, which decreases the overall volume of blood. This, in turn, helps to relax the blood vessels, making it easier for blood to flow through them.


Aldosterone antagonist/thiazide diuretic combinations are primarily used to treat hypertension. By lowering blood pressure, these medications can reduce the risk of stroke, heart attack, and other cardiovascular complications. Additionally, because thiazide diuretics also reduce fluid retention, these medications can also be used to help manage edema (fluid buildup) in conditions such as heart failure and kidney disease.

Common Brands

There are several common brands of aldosterone antagonist/thiazide diuretic combinations available on the market. Some examples include:

  1. Dyazide (hydrochlorothiazide/triamterene)

  2. Maxzide (hydrochlorothiazide/triamterene)

  3. Aldactazide (spironolactone/hydrochlorothiazide)

  4. Moduretic (amiloride/hydrochlorothiazide)

It's important to note that these are just a few examples, and there are several other brands and generic versions available.


Aldosterone antagonist/thiazide diuretic combinations are generally considered safe and well-tolerated when taken as prescribed. However, as with any medication, there are certain precautions and potential side effects to be aware of. Common side effects may include dizziness, headache, increased urination, electrolyte imbalances (such as low levels of potassium or sodium), and changes in blood sugar levels. It is important to follow the prescribed dosage and inform your healthcare provider of any existing medical conditions and other medications you may be taking. This class of medications is not recommended for use during pregnancy or while breastfeeding. If you experience any severe side effects or have concerns about the medication, it is essential to consult with your healthcare provider immediately. In conclusion, aldosterone antagonist/thiazide diuretic combinations are an effective and commonly used class of medications for managing hypertension and fluid retention. They can help to lower blood pressure, reduce the risk of cardiovascular complications, and alleviate edema. As with any medication, it is crucial to use them as prescribed and consult with a healthcare professional for personalized advice and monitoring of potential side effects.

List of Aldosterone Antagonist / Thiazide Diuretic Combinations