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This document outlines essential safety information and warnings for the use of Aldactazide, a medication combining spironolactone and hydrochlorothiazide. It highlights potential risks, necessary precautions, and steps to take in case of adverse reactions. Always discuss any concerns with your healthcare provider.

• High Potassium Levels: Aldactazide may increase potassium levels in the body, posing a risk, especially for individuals with diabetes, kidney issues, or those taking other potassium-elevating drugs. Inform your healthcare provider about your medical history and current medications. Symptoms like nausea, muscle weakness, or tingling should be reported immediately.

• Electrolyte, Blood Sugar, and Cholesterol Changes: This medication can alter levels of electrolytes such as sodium and magnesium. Regular blood tests may be required to monitor these changes. Report symptoms like fast heartbeat, muscle pain, or reduced urination to your healthcare team.

• Low Blood Pressure and Dizziness: Initial doses or increased dosages of Aldactazide can cause a significant drop in blood pressure, leading to dizziness or lightheadedness, particularly when standing. This risk is heightened by dehydration, prolonged diarrhea or vomiting, and low salt levels.

• Breast Growth or Pain: Spironolactone in Aldactazide may cause breast growth in males (gynecomastia) or breast pain in both genders. These effects are reversible upon discontinuation, although rarely permanent. Consult your doctor if you experience these symptoms to discuss alternative treatments.

• Vision Problems: Rarely, Aldactazide can cause eye pain or vision changes due to elevated eye pressure. Cease use and contact your healthcare provider if you experience these symptoms, as urgent treatment may be necessary to prevent vision loss.

• Lupus: Hydrochlorothiazide may induce lupus or exacerbate existing lupus symptoms. Notify your provider if you develop a rash, fatigue, or joint pain.

• Allergic Reactions: Individuals with sulfa drug allergies may experience similar reactions to Aldactazide. Alert your healthcare provider and pharmacist about any sulfa allergies. Seek immediate medical attention if you experience rash or breathing difficulties.

Contraindications: Do not use Aldactazide if you have the following conditions without consulting your doctor, as it may lead to serious health complications:

• Elevated potassium or calcium levels
• Addison's disease
• Anuria (not urinating)
• Certain severe kidney or liver conditions
• Allergy to sulfa or thiazide diuretics

In case of any adverse effects or concerns, contact your healthcare provider promptly.

When taking this medication, you may experience some common side effects such as dizziness, drowsiness, lightheadedness, loss of appetite, diarrhea, weakness, low blood pressure, vomiting, and low electrolyte levels like calcium, magnesium, and sodium. These effects are generally mild, but if they persist or worsen, it is advisable to consult a healthcare professional. To minimize dizziness and lightheadedness, try to rise slowly from sitting or lying down.

It's important to be aware of other potential side effects, which include fatigue, headache, breast pain or tenderness, muscle cramps, and high potassium levels. If you notice any of these, especially if they are severe, contact your healthcare provider for guidance.

There are also rare but serious side effects that warrant immediate medical attention. These include dehydration, electrolyte imbalance, joint pain, breast enlargement in men, easy bruising or bleeding, fainting, signs of kidney or liver problems (such as changes in urine output, persistent nausea or vomiting, dark urine, abdominal pain, or yellowing of skin or eyes), decrease in vision, and eye pain. Additionally, difficulty with sexual function, changes in menstrual periods, and leg cramps are also serious concerns.

In extremely rare cases, an allergic reaction may occur, presenting with symptoms like rash, itching or swelling of the face, tongue, or throat, severe dizziness, or trouble breathing. Seek emergency medical help if any of these symptoms occur. Always keep your healthcare provider informed of any side effects you experience.

Aldactazide, which contains Spironolactone and Hydrochlorothiazide, can interact with certain medications, supplements, and over-the-counter products. It is important to inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.

Some drugs, such as Dofetilide, Eplerenone, and Triamterene, should generally not be used with Aldactazide due to the risk of serious interactions. Your doctor might choose to discontinue these medications or adjust your treatment plan accordingly.

Other medications, including various ACE inhibitors (like Benazepril and Captopril), angiotensin receptor antagonists (such as Losartan and Valsartan), and nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Naproxen, may also interact with Aldactazide. In such cases, your doctor may adjust the dosage or frequency to manage potential side effects effectively.

Additionally, certain products might contain ingredients that could raise your blood pressure or worsen heart failure, such as cough-and-cold products, diet aids, and some NSAIDs. Always consult with your pharmacist to ensure safe usage when taking these products alongside Aldactazide.

Finally, Aldactazide may affect the results of certain lab tests, like parathyroid and protein-bound iodide tests. Ensure that your healthcare providers and laboratory personnel are informed about your use of this medication to interpret test results accurately.