HomeDrug ClassesCalcium Channel Blocker / ARB / Thiazide Diuretic Combinations

Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations: Uses, Common Brands, and Safety Info

"Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations are medications used to treat high blood pressure. They combine three different drugs to effectively control blood pressure levels. Common brands include Exforge HCT, Triamterene and Hydrochlorothiazide, and Azor. Safety considerations include potential side effects and the need for monitoring. Follow healthcare professional's guidance for dosage and report any concerning side effects."

Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations

Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations are a class of medications that are often used to treat hypertension, also known as high blood pressure. This medication class combines three different types of drugs to achieve a more effective and comprehensive control of blood pressure levels.


These combination medications are primarily used to lower blood pressure in individuals who have not responded well to monotherapy with a single agent. The use of multiple drugs with different mechanisms of action helps to address several underlying factors that contribute to high blood pressure.

Calcium channel blockers work by relaxing and widening the blood vessels, which reduces the resistance in the arteries and improves blood flow. ARBs (angiotensin receptor blockers) block certain receptors in the body, preventing the hormone angiotensin II from narrowing the blood vessels. Thiazide diuretics act on the kidneys to increase urine production, thereby decreasing the amount of fluid in the blood vessels and lowering blood pressure.

Combining these three drugs in a single medication allows for better control of blood pressure and offers additive effects. This class of drugs is suitable for individuals with moderate to severe hypertension or those who have not achieved adequate blood pressure control with monotherapy.

Common Brands

Several pharmaceutical companies produce Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations. Some common brand names include:

  • Exforge HCT: A combination of amlodipine (calcium channel blocker), valsartan (ARB), and hydrochlorothiazide (thiazide diuretic).

  • Triamterene and Hydrochlorothiazide: This medication combines hydrochlorothiazide (thiazide diuretic) with triamterene, a potassium-sparing diuretic. It may also be used in combination with other calcium channel blockers or ARBs.

  • Azor: Azor is a combination of amlodipine (calcium channel blocker) and olmesartan (ARB).

It is important to note that brand names vary depending on the country and region, and it's essential to consult with a healthcare professional to determine the availability and appropriate choice of medication.


As with any medication, Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations have potential side effects and safety considerations. Some individuals may experience dizziness, headache, increased urination, or electrolyte imbalances when taking these medications, particularly due to the diuretic component.

Prior to starting this medication class, it is crucial for individuals to undergo a thorough medical evaluation, provide a detailed medical history, and inform their healthcare professional of any existing medical conditions or current medications. In some cases, these combinations may not be suitable due to specific contraindications or potential drug interactions.

Regular monitoring of blood pressure and laboratory tests, including electrolytes and kidney function, is typically recommended for individuals taking Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations to ensure the medication's effectiveness and safety.

It is essential to follow the prescribed dosage and any guidance provided by a healthcare professional when taking these medications. If any concerning side effects or changes in health occur, it is important to seek immediate medical attention

List of Calcium Channel Blocker / ARB / Thiazide Diuretic Combinations