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This medication comes with critical safety information that should be carefully considered before use. It is essential to be aware of potential risks and precautions to ensure safe administration. Please review the following points and consult your healthcare provider for any concerns or questions.

• Pregnancy Risk: This drug may cause significant harm, potentially fatal, to an unborn child. It is crucial to avoid pregnancy while taking this medication. Discuss effective birth control methods with your doctor. If you are planning to become pregnant, suspect you are pregnant, or are already pregnant, inform your healthcare provider immediately.

• Low Blood Pressure: The medication can lead to a significant drop in blood pressure, causing symptoms such as dizziness, fatigue, or lightheadedness. This is more likely at the beginning of treatment or with an increased dosage. Stay hydrated to mitigate this risk, and contact your healthcare team if symptoms occur. Seek urgent medical attention if you experience a fall due to dizziness. Factors increasing this risk include dehydration, prolonged diarrhea or vomiting, low salt levels, taking high doses of diuretics, and a history of narrow heart valves.

• Heart Attack or Chest Pain: Though rare, there is a risk of worsening chest pain or heart attack, especially when starting the medication or increasing the dose. This risk is higher for individuals with coronary artery disease. If you experience chest pain, pressure, heartburn, dizziness, or breathing difficulties, seek immediate medical assistance.

• Kidney Function: While ARBs like olmesartan in this medication may protect the kidneys, they can also impair kidney function in some individuals. This risk is elevated for those with severe heart failure, existing kidney issues, or who take other medications affecting kidney health. Report any urinary issues to your healthcare provider.

• Electrolyte, Blood Sugar, and Cholesterol Changes: The medication can alter sodium, potassium, magnesium levels, and affect blood sugar and cholesterol levels. Be cautious if you are on other medications that impact these levels.

• Lupus Risk: Hydrochlorothiazide, a component of this drug, may trigger or worsen lupus symptoms. If you notice extreme fatigue, joint pain, or a rash on your cheeks and nose, consult your healthcare provider.

• Vision Changes: Rarely, hydrochlorothiazide can cause vision changes or eye pain. Report any visual disturbances to your doctor promptly, as untreated symptoms could result in permanent vision loss. This is more common in individuals with sulfa or penicillin allergies.

• Severe Diarrhea: Olmesartan may cause severe diarrhea, known as sprue-like enteropathy, potentially occurring long after starting the medication. This can lead to weight loss, stomach pain, fatigue, nausea, and vomiting. If severe diarrhea persists, seek medical attention and maintain hydration with fluids and electrolytes.

Contraindications: Do not use this medication if you have conditions such as an inability to urinate or if you are taking aliskiren (Tekturna) and have diabetes. Always discuss your medical history with your healthcare provider before starting this medication.

When taking this medication, you may experience some common side effects such as dizziness, swelling of the legs or arms, headache, tiredness, and symptoms resembling a common cold. These effects are generally mild, but if they persist or worsen, it’s advisable to consult your healthcare provider. Additionally, other side effects like muscle spasms, nausea, upper respiratory tract infection, diarrhea, urinary tract infection, and joint swelling have been reported. While these are less common, they may still occur and should be discussed with your healthcare provider if they become concerning.

There are also rare but serious side effects that necessitate immediate medical attention. These include dangerously low blood pressure, which can present as dizziness, lightheadedness, or fainting. Heart attack symptoms such as chest pain, cold and clammy skin, or sweating should be treated as emergencies. Kidney problems may manifest as confusion, severe tiredness, or decreased urination, while abnormal electrolyte levels can cause muscle cramps or a fluttering heartbeat. Vision changes and eye pain are also serious, as is severe diarrhea characterized by frequent watery bowel movements. Lastly, a severe allergic reaction, indicated by rash, difficulty breathing, or swelling of the face, lips, or throat, requires urgent medical care.

While many people use this medication without experiencing significant issues, it’s important to be aware of these potential side effects and to seek medical advice if you notice anything unusual. Your healthcare provider can help you manage any side effects and determine the best course of action.

Tribenzor can interact with various drugs, so it's important to inform your doctor and pharmacist about any other medications or supplements you are taking. This includes prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Here are some key interactions to be aware of:

1. Medications Not Recommended with Tribenzor:

   • Aliskiren and Dofetilide: Using these medications with Tribenzor is not advised. Your doctor may choose alternative treatments or adjust your current medications.

2. Medications Usually Not Recommended but Sometimes Necessary:

   • Examples Include: Benazepril, Lisinopril, Ibuprofen, Naproxen, and many others.
   • If prescribed together, your healthcare provider may alter dosages or frequency to manage any potential risks.

3. Medications That May Increase Risk of Side Effects:

   • Examples Include: Ibuprofen, Diclofenac, Naproxen, among others.
   • Combining these with Tribenzor might heighten the chance of side effects. Your doctor will carefully consider the benefits and risks before prescribing them together.

Additionally, some products might elevate blood pressure, so consult your pharmacist on how to use products safely, especially those for coughs, colds, diet aids, or NSAIDs like ibuprofen and naproxen. Also, Tribenzor can interfere with certain lab tests, leading to inaccurate results. Ensure that all lab personnel and healthcare providers are aware that you are using this medication.