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GC-C Agonists: Uses, Common Brands, and Safety Info

GC-C agonists are a class of drugs used to treat chronic constipation and irritable bowel syndrome with constipation. They activate the GC-C receptor in the gastrointestinal tract, increasing fluid secretion and promoting bowel movements. Common brands include Linzess and Trulance. Side effects may include diarrhea and abdominal pain. Use during pregnancy and breastfeeding should be discussed with a healthcare provider. Precautions should be taken for individuals with certain gastrointestinal conditions.

GC-C Agonists

GC-C agonists refer to a class of drugs that target and activate the guanylate cyclase C (GC-C) receptor found in the gastrointestinal tract. These medications offer therapeutic benefits for various conditions affecting the digestive system. By binding to the GC-C receptor, they stimulate the production of cyclic guanosine monophosphate (cGMP), which regulates numerous physiological processes within the intestines.


GC-C agonists are primarily used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. These conditions can cause persistent discomfort, abdominal pain, bloating, and changes in bowel habits. GC-C agonists help alleviate these symptoms by increasing the fluid secretion in the intestines and promoting bowel movements. Additionally, these drugs have shown efficacy in reducing abdominal pain associated with IBS-C.

Common Brands

Some commonly prescribed GC-C agonists include: - Linzess (linaclotide): This medication is available in capsule form and is approved for the treatment of CIC and IBS-C. - Trulance (plecanatide): It is also available in tablet form and used for the management of CIC in adults. It's important to note that these are just a few examples, and other GC-C agonists may also be available depending on the region and prescribing practices.


GC-C agonists generally have a good safety profile when used as prescribed. However, it is essential to consider some safety information before starting these medications: - Common side effects: The most commonly reported side effects of GC-C agonists include diarrhea, abdominal pain, bloating, and flatulence. These effects are generally mild to moderate and tend to diminish over time. - Use during pregnancy and breastfeeding: The safety of GC-C agonists in pregnant or breastfeeding individuals has not been fully established. It is recommended to consult with a healthcare provider before using these medications during these periods. - Drug interactions: It is crucial to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements, as GC-C agonists may interact with these substances. - Precautions: GC-C agonists should be used with caution in individuals with known gastrointestinal obstructions, severe inflammatory bowel disease, diverticulitis, or a history of bowel perforation. As with any medication, it is essential to follow the prescribed dosage and instructions provided by your healthcare professional. If you experience any severe or persistent side effects, it is important to seek medical attention promptly. In conclusion, GC-C agonists are a valuable class of medications used to manage chronic idiopathic constipation and irritable bowel syndrome with constipation. Through their action on the GC-C receptor, they help relieve symptoms such as abdominal pain, bloating, and irregular bowel habits. As with all medications, it is important to understand their uses, common brands, and safety precautions before initiating therapy.

List of GC-C Agonists