HomeDrug ClassesLocal Anesthetic / NSAID Combinations

Local Anesthetic / NSAID Combinations: Uses, Common Brands, and Safety Info

"Local anesthetic/NSAID combinations are medications that provide pain relief and reduce inflammation. They are commonly used for joint or muscle pain, postoperative pain, and dental pain. Popular brands include Synera, Anbesol, and EMLA cream. When used as directed, they are generally safe, but precautions should be taken regarding allergic reactions and side effects."


Local anesthetic/NSAID combinations are medications that combine a local anesthetic and a nonsteroidal anti-inflammatory drug (NSAID) into a single formulation. These drugs are commonly used to provide both pain relief and reduce inflammation at the site of application. By combining the benefits of both local anesthetics and NSAIDs, these medications can effectively manage pain and inflammation associated with various conditions.


Local anesthetic/NSAID combinations are primarily used for the relief of pain and inflammation in specific areas of the body. They are often applied topically to the skin or mucous membranes, allowing for localized effects. These medications are commonly prescribed for conditions such as joint or muscle pain, postoperative pain, minor injuries, and dental pain. Local anesthetic/NSAID combinations can also be used as part of a comprehensive approach to pain management, in conjunction with other medications or therapies.

Common Brands

There are several common brands of local anesthetic/NSAID combinations available in the market. Here are a few examples: 1. Lidocaine/Tetracaine: This combination is commonly found in topical creams or gels. Brand names include Synera and Pliaglis. 2. Benzocaine/Oxybuprocaine: This combination is often used as a topical anesthetic for minor procedures or dental work. It is available under the brand name Anbesol. 3. Lidocaine/Prilocaine: Frequently used as a local anesthetic for procedures involving intact skin, this combination is found in products like EMLA cream and Oraqix. It is important to note that the availability of specific brands may vary depending on your location and healthcare provider.


Local anesthetic/NSAID combinations are generally considered safe when used as directed. However, as with any medication, there are certain precautions to keep in mind: 1. Follow instructions: Always carefully follow the dosing instructions provided by your healthcare provider or as indicated on the packaging. Using more than the recommended amount can increase the risk of side effects. 2. Allergic reactions: Some individuals may be allergic to certain local anesthetics or NSAIDs. If you experience symptoms such as rash, hives, or difficulty breathing after applying the medication, seek immediate medical attention. 3. Side effects: Common side effects may include skin irritation, redness, or a temporary numbing sensation at the application site. If these symptoms persist or worsen, consult your healthcare provider. 4. Precautions: It is important to inform your healthcare provider about any pre-existing medical conditions or allergies you may have before using a local anesthetic/NSAID combination. This will help ensure its safety and effectiveness for you. As with any medication, it is recommended to consult with your healthcare provider or pharmacist before starting any new treatment regimen. They can provide personalized advice based on your medical history and specific needs. Please note that this description does not constitute medical advice, and you should always consult with a healthcare professional for specific concerns or questions regarding your health.

List of Local Anesthetic / NSAID Combinations