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ZYNRELEF is a medication used to manage pain after certain surgical procedures. While it can be effective, it's important to be aware of potential risks associated with its use.

Cardiovascular Risks: ZYNRELEF contains a nonsteroidal anti-inflammatory drug (NSAID), which can increase the risk of serious cardiovascular events like heart attacks and strokes. These events can occur early in treatment and may become more likely with prolonged use. Therefore, ZYNRELEF should not be used in patients undergoing coronary artery bypass graft (CABG) surgery.

Gastrointestinal Risks: NSAIDs can also lead to serious gastrointestinal issues, including bleeding, ulcers, and perforation of the stomach or intestines. These complications can happen without warning and may be fatal. Elderly individuals and those with a history of peptic ulcer disease or gastrointestinal bleeding are at a higher risk.

Allergic Reactions: Some individuals may experience severe allergic reactions to ZYNRELEF, especially if they have a history of asthma, hives, or other allergic-type reactions after taking aspirin or other NSAIDs. Such reactions can be life-threatening and require immediate medical attention.

Liver and Kidney Concerns: ZYNRELEF may cause liver damage, so it's important to monitor liver function during treatment. Additionally, it can affect kidney function, particularly in patients with existing kidney issues, heart failure, or those who are dehydrated. In severe cases, it may lead to kidney failure.

Heart Failure and Edema: The use of NSAIDs like ZYNRELEF can result in fluid retention and swelling, which may worsen existing heart failure. Patients with severe heart failure should only use ZYNRELEF if the benefits outweigh the risks.

Blood Pressure Effects: ZYNRELEF can cause new or worsening high blood pressure, which may increase the risk of cardiovascular events. Patients taking blood pressure medications should be aware that NSAIDs can reduce the effectiveness of these treatments.

Skin Reactions: Serious skin reactions, including life-threatening conditions like Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported with NSAID use. If any skin rash or signs of hypersensitivity occur, discontinue use and seek medical attention immediately.

Pregnancy Risks: Using ZYNRELEF during pregnancy, especially after 20 weeks, can harm the developing fetus, potentially leading to kidney problems and low amniotic fluid levels. It's advised to avoid using ZYNRELEF during pregnancy unless absolutely necessary.

Cartilage Damage: Animal studies have shown that injecting ZYNRELEF directly into joints can cause cartilage damage. Therefore, it should not be used for intra-articular (within the joint) injections.

Methemoglobinemia: Although rare, local anesthetics like bupivacaine, a component of ZYNRELEF, can cause methemoglobinemia—a condition where the blood carries less oxygen. Symptoms include pale or blue-colored skin, shortness of breath, fatigue, and rapid heart rate. Seek immediate medical attention if these occur.

It's crucial to discuss your medical history and any concerns with your healthcare provider before using ZYNRELEF to ensure it's appropriate for your situation.

Zynrelef is a medication used to manage post-surgical pain. While it can be effective, it's important to be aware of potential side effects that may occur. Common Side Effects:

• Gastrointestinal Issues: Nausea and vomiting are frequently reported.
• Constipation: This may occur, especially following orthopedic procedures.
• Headache: Some patients experience headaches after administration.
• Dizziness: A sensation of lightheadedness or unsteadiness can occur.
• Incision Site Reactions: Swelling, redness, or delayed healing at the surgical site have been observed. Serious Side Effects:
• Cardiovascular Events: Nonsteroidal anti-inflammatory drugs (NSAIDs) like meloxicam, a component of Zynrelef, may increase the risk of serious cardiovascular events, including heart attack and stroke.
• Gastrointestinal Bleeding: NSAIDs can cause serious gastrointestinal issues such as bleeding, ulcers, and perforation of the stomach or intestines, which can be fatal.
• Allergic Reactions: Severe allergic responses, including anaphylaxis, have been reported. Symptoms may include difficulty breathing, swelling of the face or throat, and hives.
• Skin Reactions: Serious skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis can occur, presenting as severe rashes, blistering, or peeling skin.
• Liver and Kidney Issues: Elevated liver enzymes and kidney dysfunction have been noted.
• Methemoglobinemia: A rare blood disorder that reduces oxygen delivery to tissues, leading to symptoms like pale or blue-colored skin, headache, and rapid heart rate. Precautions:
• Pregnancy: Avoid using Zynrelef during the later stages of pregnancy due to potential risks to the unborn baby.
• Heart Conditions: Patients with severe heart failure should use Zynrelef only if the benefits outweigh the risks.
• Renal Impairment: Not recommended for patients with severe kidney impairment. If you experience any severe or concerning side effects after receiving Zynrelef, contact your healthcare provider immediately. Always discuss your medical history and any current medications with your doctor before undergoing treatment with Zynrelef to ensure it's appropriate for your situation.

When using ZYNRELEF, it's important to be aware of potential interactions with other medications:

• Blood Thinners and Antidepressants: Combining ZYNRELEF with anticoagulants (like Warfarin), antiplatelet agents (such as Aspirin), or certain antidepressants (including SSRIs and SNRIs) can increase the risk of bleeding.

• Blood Pressure Medications: ZYNRELEF may reduce the effectiveness of medications like ACE inhibitors, ARBs, and beta-blockers, potentially leading to higher blood pressure.

• Diuretics: The effectiveness of diuretics, commonly known as "water pills," may be diminished when taken with ZYNRELEF.

• Other NSAIDs and Salicylates: Using ZYNRELEF alongside other NSAIDs or salicylates (such as aspirin) can increase the risk of gastrointestinal issues, including ulcers and bleeding.

• Local Anesthetics: Avoid using additional local anesthetics within 96 hours after receiving ZYNRELEF, as this can increase the risk of side effects.

• Medications Associated with Methemoglobinemia: Certain drugs, including nitrates, some antibiotics, and specific antimalarials, can increase the risk of a condition called methemoglobinemia when used with ZYNRELEF.

• Other Specific Medications: ZYNRELEF may interact with Digoxin, Lithium, Methotrexate, Cyclosporine, and pemetrexed, potentially leading to increased side effects or reduced effectiveness.

Always inform your healthcare provider about all medications and supplements you are currently taking to ensure safe use of ZYNRELEF.