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Polypeptide / Antifolate Antibiotic Combinations: Uses, Common Brands, and Safety Info

Polypeptide/antifolate antibiotic combinations are effective for treating bacterial infections caused by gram-negative bacteria. Common brands include Bactrim, Zosyn, Augmentin, and Merrem. They are generally safe, but side effects and precautions should be considered. Completing the full course of treatment is important for maximum efficacy.

Polypeptide / Antifolate Antibiotic Combinations

Polypeptide/antifolate antibiotic combinations are a class of medications that consist of both a polypeptide antibiotic and an antifolate antibiotic. These combinations are used to treat a variety of bacterial infections and are particularly effective against certain types of bacteria that have become resistant to other antibiotics.


Polypeptide/antifolate antibiotic combinations are primarily used to treat infections caused by gram-negative bacteria, including certain strains that are resistant to other antibiotics. These combinations are commonly used to treat infections in the respiratory tract, urinary tract, skin and soft tissues, as well as certain types of intra-abdominal and bone infections.

The polypeptide component of this class of antibiotics works by disrupting the cell walls of bacteria, leading to their death. The antifolate component works by inhibiting the synthesis of folic acid, which is essential for the growth and reproduction of bacteria. By combining both mechanisms of action, polypeptide/antifolate antibiotic combinations can effectively eradicate bacterial infections.

Common Brands

There are several common brands of polypeptide/antifolate antibiotic combinations available on the market. Some examples include:

  • Trimethoprim/sulfamethoxazole (Bactrim, Septra)

  • Piperacillin/tazobactam (Zosyn)

  • Amoxicillin/clavulanic acid (Augmentin)

  • Meropenem/clavulanate (Merrem)

These are just a few examples, and it's important to note that there are various other polypeptide/antifolate antibiotic combinations available, each with their own specific indications and formulations.


When used as prescribed, polypeptide/antifolate antibiotic combinations are generally safe and well-tolerated. However, like any medication, there can be potential side effects and precautions that need to be considered.

Common side effects may include nausea, vomiting, diarrhea, or allergic reactions such as rash or itching. It is important to consult with a healthcare professional if any concerning side effects occur.

Some individuals may have specific contraindications or precautions associated with certain polypeptide/antifolate antibiotic combinations due to underlying medical conditions or medications they are taking. It is essential to inform your healthcare provider about any existing medical conditions or medications to ensure the safe and effective use of these antibiotics.

As with any antibiotics, it is crucial to complete the full course of treatment as prescribed, even if symptoms improve before completion. This helps to prevent the development of antibiotic resistance and ensures the full eradication of the bacterial infection.

In summary, polypeptide/antifolate antibiotic combinations are a class of medications used to effectively treat bacterial infections, particularly those caused by gram-negative bacteria. They can be found under various brand names and are generally safe when used as directed. However, as with any medication, it is important to follow medical advice, report any concerning side effects, and complete the full course of treatment to maximize efficacy.

List of Polypeptide / Antifolate Antibiotic Combinations