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This document provides essential safety information regarding the use of Polytrim (polymyxin B / trimethoprim) eye drops. It is important to be aware of potential risks and precautions when using this medication. Please read the following points and consult your healthcare provider if you have any questions or concerns:

• Intended Use: Polytrim eye drops are specifically designed for application on the eye's surface and should not be used on any other part of the body.

• Risk of New Infections: Prolonged use of Polytrim may lead to new infections from fungi or bacteria resistant to the medication. Use it only as prescribed, and contact your healthcare provider if symptoms persist or if new symptoms arise.

• Contact Lens Precaution: Polytrim contains benzalkonium chloride, a preservative that can be absorbed by soft contact lenses, potentially damaging them. If your healthcare provider allows contact lens use during treatment, remove them before applying the drops and wait at least 15 minutes before reinserting them.

• Contraindications: Do not use this medication if you have a known severe allergy to polymyxin B or trimethoprim. Discuss any allergies with your healthcare provider before starting treatment.

For your safety, always adhere to these guidelines and promptly report any adverse reactions or concerns to your healthcare professional.

When using this medication, some individuals may experience mild side effects such as temporary eye irritation, which can include symptoms like redness, burning, stinging, or itchiness. These effects are generally not serious but should be monitored. If they persist or worsen, it is advisable to consult a healthcare provider. Additionally, some users might notice swollen eyelids, red eyes, or increased tearing. These are also common and typically mild but should be addressed if they become bothersome.

Prolonged or repeated use of this medication may lead to other types of eye infections, including fungal infections. It is important to be vigilant for new symptoms such as eye pain, swelling, thick discharge, or pus, and to contact a healthcare provider if these occur.

Serious allergic reactions to this medication are rare but require immediate attention. Symptoms of a severe allergic reaction include hives, difficulty breathing, and swelling of the eyes, face, tongue, or throat. If you experience any of these, seek urgent medical care. While this list includes the most commonly reported side effects, it is not exhaustive. If you notice any other unusual symptoms, discussing them with a healthcare provider is recommended.