HomeDrug ClassesRenin Inhibitors

Renin Inhibitors: Uses, Common Brands, and Safety Info

Renin inhibitors are drugs used to treat hypertension by blocking the action of renin, an enzyme involved in blood pressure regulation. Common brands include Tekturna. They are generally safe but may cause side effects like diarrhea and dizziness. Not recommended during pregnancy.

Renin Inhibitors

Renin inhibitors are a class of drugs used primarily to treat hypertension, or high blood pressure. These medications work to reduce blood pressure by blocking the action of renin, an enzyme produced by the kidneys that plays a vital role in the regulation of blood pressure and fluid balance in the body. Renin inhibitors help to relax and widen blood vessels, consequently improving blood flow and reducing the workload on the heart.


Renin inhibitors are mainly prescribed for individuals with essential hypertension, which refers to high blood pressure without any identifiable cause. By inhibiting renin, these drugs effectively lower blood pressure and help maintain it at a healthy level. They are often used as a second-line treatment option when other classes of antihypertensive drugs, such as ACE inhibitors or calcium channel blockers, have proven ineffective or caused intolerable side effects. Additionally, renin inhibitors have shown promise in the management of certain kidney conditions, such as diabetic nephropathy, which is kidney damage caused by diabetes. They may slow down the progression of kidney disease and help preserve kidney function in individuals with these conditions.

Common Brands

One of the well-known renin inhibitors is aliskiren, which is sold under the brand name Tekturna. Aliskiren was the first drug in its class to be approved for the treatment of hypertension. Other renin inhibitors include aliskiren/hydrochlorothiazide combinations, available under different brand names. It is important to note that while renin inhibitors can effectively lower blood pressure, they are not typically the first choice among antihypertensive medications. They are generally reserved for specific cases where other medication options have been exhausted.


Like any medication, renin inhibitors may have potential side effects and some precautions that should be taken into consideration. Most commonly reported side effects include diarrhea, cough, dizziness, and skin rashes. It is important to inform your healthcare provider about any pre-existing medical conditions or medications you are taking to ensure the renin inhibitor is appropriate for you. Renin inhibitors are generally considered safe for most individuals; however, they are not recommended for use during pregnancy due to potential risks to the fetus. As with any medication, it is crucial to follow your healthcare provider's instructions and attend regular check-ups to monitor your response to the drug and check for any adverse effects. In summary, renin inhibitors are a class of drugs used primarily to treat hypertension when other antihypertensive medications have not been effective or caused intolerable side effects. They work by blocking the action of renin, a key enzyme involved in the regulation of blood pressure. Renin inhibitors can be beneficial in managing high blood pressure and certain kidney conditions, offering an alternative option for individuals who require additional blood pressure control.

List of Renin Inhibitors