HomeDrug ClassesTriptan / NSAID Combinations

Triptan / NSAID Combinations: Uses, Common Brands, and Safety Info

"Triptan / NSAID combinations combine a triptan and an NSAID to effectively treat migraines. Common brands include Treximet, Limbitrol, and Zomig. These combinations are generally safe, but precautions should be taken. Side effects may occur, and individuals with certain medical conditions should use caution. Adherence to recommended dosages and seeking medical attention for persistent or worsening symptoms is essential."

Triptan / NSAID Combinations

Triptan / NSAID combinations are a class of medications that combine a triptan, a type of medication that targets migraines and cluster headaches, with a nonsteroidal anti-inflammatory drug (NSAID). This combination therapy offers a synergistic effect in treating migraines by addressing both the pain and inflammation often associated with these debilitating headaches.


This drug class is primarily used for the acute treatment of migraines with or without aura. The combination of a triptan and an NSAID helps to relieve migraine symptoms such as severe headache, nausea, vomiting, and sensitivity to light and sound. By combining these two medications, the effectiveness of pain relief is enhanced, and the duration and severity of a migraine can be reduced.

Common Brands

Several common brands of triptan / NSAID combinations are available on the market. These include:

  • Sumatriptan/Naproxen (Treximet)

  • Rizatriptan/Aspirin (Limbitrol)

  • Zolmitriptan/Naproxen (Zomig)

It's important to consult with a healthcare professional to determine which specific brand and dosage is most suitable for an individual's unique needs.


Triptan / NSAID combinations are generally safe when used as directed. However, as with any medication, there are potential side effects and precautions to consider. Common side effects may include dizziness, drowsiness, dry mouth, and upset stomach. In some cases, more serious side effects such as chest pain, severe allergic reactions, or stomach ulcers may occur, although these are rare.

It's crucial to discuss any existing medical conditions, allergies, or current medications with a healthcare professional before starting a triptan / NSAID combination. Certain individuals, such as those with a history of heart problems, liver or kidney disease, or stomach ulcers, may need to avoid or use these combinations with caution. Pregnant or breastfeeding individuals should also consult their healthcare provider before using these medications.

As with all drugs, it's important to adhere to the recommended dosage and not exceed the prescribed amount. If migraines persist or worsen despite treatment or if new or unexpected symptoms occur, prompt medical attention should be sought.

In conclusion, triptan / NSAID combinations provide an effective and convenient option for the acute treatment of migraines. By combining the pain-relieving properties of a triptan with the anti-inflammatory effects of an NSAID, these combinations can help alleviate migraine symptoms and improve the overall quality of life for individuals suffering from migraines.

List of Triptan / NSAID Combinations