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The use of Treximet, which contains naproxen and sumatriptan, comes with several important safety considerations. It is crucial to be informed about these potential risks and precautions before taking this medication. Please review the following information carefully and discuss any concerns with your healthcare provider.

• Heart Risks: Treximet may increase the risk of heart attack, stroke, or chest pain due to blood clots, especially if taken for an extended period or in higher doses. Individuals with existing heart issues, those who have undergone or are planning heart surgery, should avoid this medication.

• Stomach and Intestinal Risks: The naproxen in Treximet, a nonsteroidal anti-inflammatory drug (NSAID), can cause serious stomach issues like ulcers and bleeding, which may occur without warning. Those with a history of peptic ulcers, stomach bleeding, or severe liver problems should be particularly cautious.

• Blood Pressure and Heart Failure: NSAIDs can lead to fluid retention, increasing blood pressure and the risk of heart failure. Individuals with high blood pressure or heart failure should inform their healthcare provider before use.

• Arrhythmias: Treximet can cause serious heart rhythm issues, especially in individuals with pre-existing conditions that affect heart rhythms. Symptoms like chest pain, dizziness, or trouble breathing need immediate attention.

• Vascular Concerns: Sumatriptan can cause severe narrowing of blood vessels, which may affect blood supply to different body parts.

• Serotonin Syndrome: This rare but serious condition can occur if Treximet is taken with other drugs that increase serotonin levels. It's important to discuss all medications with your healthcare provider.

• Liver and Kidney Damage: Long-term use of NSAIDs can lead to liver and kidney issues. Those with existing liver or kidney conditions, or who are taking other potentially harmful medications, should exercise caution.

• Allergic Reactions: Treximet can cause severe allergic responses, including anaphylaxis. Patients with aspirin or NSAID allergies should avoid this medication.

• Pregnancy: Treximet may harm an unborn baby, especially during the second half of pregnancy, and should be avoided.

In case of any rare but serious side effects, such as persistent stomach pain, black stools, unusual chest pain, or changes in vision, seek medical assistance immediately.

Contraindications:

• Previous allergic reactions to sumatriptan or naproxen.
• History of asthma, hives, or allergies to NSAIDs.
• Use around coronary artery bypass graft surgery.
• Uncontrolled high blood pressure, coronary artery disease, or vasospasm conditions.
• History of stroke, certain migraines, or peripheral vascular disease.
• Severe liver problems.
• Recent use of ergot medicines, other triptans, or monoamine oxidase inhibitors.

Always consult with a healthcare provider before starting Treximet to ensure it is safe based on your health history and current medications.

When taking this medication, you might experience some common side effects such as dizziness, sleepiness, nausea, chest pain or discomfort, and sensations of pain, tightness, or pressure in the neck, throat, or jaw. Some people also report a "pins and needles" feeling, indigestion, dry mouth, sudden warmth or flushing, and muscle tightness. These effects are generally mild, but if they persist or worsen, consult your healthcare provider for advice.

More serious side effects, although rare, require immediate medical attention. These include anemia and high potassium levels. Additionally, watch for symptoms such as blue fingers or toes, cold extremities, difficulty or painful swallowing, easy bruising, hearing changes, mood alterations, and signs of kidney issues like changes in urination. Symptoms of heart issues such as swelling in the ankles or feet, unusual tiredness, rapid weight gain, or tightness and pain resembling that of a heart attack should also be urgently addressed.

The medication can increase blood pressure, so regular monitoring is advisable. Rarely, it can cause severe liver disease or serotonin syndrome, especially if taken with other serotonin-boosting drugs. Symptoms to watch for include persistent nausea or vomiting, loss of appetite, dark urine, yellowing of the eyes or skin, fast heartbeat, hallucinations, severe dizziness, and unexplained fever. Allergic reactions are also rare but serious, marked by fever, swollen lymph nodes, rash, severe dizziness, or trouble breathing. If any of these occur, seek medical help immediately. Always communicate any other unexpected effects with your healthcare provider.

This medication can interact with several other drugs. It is important to be aware of these interactions to avoid potential harm:

1. Blood Pressure and Heart Medications: This drug may interact with aliskiren, ACE inhibitors (like captopril and lisinopril), and angiotensin II receptor blockers (such as losartan and valsartan). Diuretics, often called "water pills" (e.g., furosemide), and corticosteroids like prednisone can also interact with this medication.

2. MAO Inhibitors: Combining this medication with MAO inhibitors (such as isocarboxazid, linezolid, and others) can lead to a dangerous, possibly fatal, reaction. MAO inhibitors should not be taken during treatment or for two weeks before starting this medication. Consult your doctor for guidance on when to start or stop these medications.

3. Serotonin Syndrome Risk: There is an increased risk of serotonin syndrome when this medication is used with drugs that increase serotonin levels. These include some street drugs like MDMA, St. John's wort, and certain antidepressants (like SSRIs and SNRIs). The risk is higher when starting or increasing the dose of these drugs.

4. Increased Bleeding Risk: This medication can heighten the risk of bleeding if taken with other drugs that have similar effects, such as anti-platelet drugs (e.g., clopidogrel) and blood thinners (like warfarin and dabigatran).

5. Pain Relievers/Fever Reducers: Be cautious with other pain relievers or fever reducers, such as NSAIDs (ibuprofen, celecoxib) and aspirin, as they may increase the risk of side effects when used with this medication. If prescribed low-dose aspirin for heart health, continue as directed by your doctor, but discuss the use of naproxen, as it may reduce aspirin's effectiveness in preventing heart attacks or strokes.

6. Ergotamine and Triptans: If you are taking ergotamine medications or "triptan" drugs, you will need to space out the doses from this medication to minimize severe side effects. Ask your doctor for the appropriate timing between doses.

7. Lab Test Interference: This medication might affect the results of certain lab tests, like bleeding times and adrenal function tests. Ensure all healthcare providers and lab personnel are aware you are taking this medication.

Always consult your healthcare provider for more detailed information and before making any changes to your medication regimen.