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Urease Inhibitors: Uses, Common Brands, and Safety Info

Urease inhibitors are drugs that block the enzyme urease, used to treat H. pylori infection. Common brands include Acetohydroxamic Acid and Nifuratel. It is generally safe but may cause gastrointestinal side effects. Consult a healthcare provider for proper usage.

Urease Inhibitors

Urease inhibitors are a class of drugs that work by blocking the activity of the enzyme urease. Urease is responsible for the breakdown of urea into ammonia and carbon dioxide in the body. By inhibiting this enzyme, urease inhibitors have the ability to reduce the production of ammonia, which can be beneficial in certain medical conditions.


The primary use of urease inhibitors is in the treatment of Helicobacter pylori (H. pylori) infection, a type of bacterial infection that commonly affects the stomach and the first part of the small intestine. When H. pylori infects the stomach, it releases the enzyme urease, which helps it survive in the acidic environment of the stomach by neutralizing the acid. Urease inhibitors can be used in combination with other antibiotics to suppress the growth of H. pylori and aid in the eradication of the infection.

Common Brands

Some common brands of urease inhibitors include Acetohydroxamic Acid (AHA), which is used for the treatment of certain types of urinary tract infections, and Nifuratel, which is primarily used in the treatment of H. pylori infection and associated gastrointestinal disorders. It is important to note that the availability of specific brands may vary depending on the country and region.


Urease inhibitors are generally safe and well-tolerated when used as directed by a healthcare professional. However, like any medication, they may have potential side effects. Common side effects may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, or abdominal pain. It is important to consult with a healthcare provider if any of these symptoms persist or worsen. As with any medication, it is essential to inform your healthcare provider about any other drugs or medical conditions you have before starting treatment with urease inhibitors. They may interact with certain medications, and dose adjustments may be necessary to avoid potential drug interactions or adverse effects. It is recommended to follow the prescribed dosage and duration of treatment as advised by the healthcare professional. Abruptly discontinuing the use of urease inhibitors or altering the dosage without medical supervision may affect the efficacy of treatment. In summary, urease inhibitors are a class of drugs commonly used in the treatment of H. pylori infection. They work by inhibiting the urease enzyme, reducing the production of ammonia in the body. Common brands of urease inhibitors include Acetohydroxamic Acid (AHA) and Nifuratel. While generally safe, it is important to be aware of potential side effects and consult a healthcare provider for guidance when using these medications.

List of Urease Inhibitors