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This safety information for Lithostat (acetohydroxamic acid) outlines important precautions and potential risks related to its use. Please review the following details carefully and consult your healthcare provider with any questions or concerns.

• Low Blood Cell Count (Anemia): Lithostat may lead to hemolytic anemia, where red blood cells are broken down faster than they are produced. This condition can result in symptoms such as nausea, vomiting, appetite loss, and fatigue. If you experience these symptoms, inform your healthcare provider. Regular monitoring of blood cell counts will be conducted during your treatment.

• Birth Defects: There is a risk of harm to pregnant women and their unborn babies from Lithostat. Women of childbearing age should use effective birth control while taking this medication. Notify your provider immediately if you become pregnant during treatment. The use of Lithostat is contraindicated in pregnancy.

• Liver Issues and Cancer Risk: Though rare, Lithostat may cause liver problems or increase the risk of liver cancer. Research has shown that acetamide, a breakdown product of Lithostat, can cause cancer in rats at extremely high doses. Your liver function will be closely monitored by your healthcare provider.

• Kidney Disease History: If you have a history of kidney disease, discuss the risks with your healthcare provider before starting Lithostat.

• Interaction with Iron: Lithostat can interact with iron-containing medications, which may affect its efficacy. Inform your healthcare provider if you are taking any iron supplements or medications.

In case of any contraindications, such as urinary infections that do not produce urease, infections manageable with antibiotics, poor kidney function, or if you are a woman not using birth control, consult your healthcare provider prior to using Lithostat.

When taking this medication, some individuals may experience mild side effects such as headaches, nausea, vomiting, stomach upset, loss of appetite, shakiness, nervousness, depression, anxiety, and fatigue. These effects are generally not severe and often diminish over time. However, if they persist or worsen, it's wise to consult your healthcare provider for advice.

There are other side effects that can occur, including hair loss, rash, and changes in your blood tests such as hemolytic anemia and reticulocytosis. Some users have also reported inflamed veins and a racing heart. While these are less common, it's important to monitor how you feel and contact your healthcare provider if these symptoms appear.

In rare instances, serious side effects may occur, requiring immediate medical attention. These include a fast or pounding heartbeat, unusual tiredness, weakness, dark urine, mental or mood changes, easy bruising or bleeding, and signs of infection like a persistent sore throat or fever. Additionally, watch for signs of a blood clot in the leg, characterized by redness, swelling, throbbing, or pain in one leg, as well as serious allergic reactions such as rash, itching, severe dizziness, or trouble breathing. Always seek urgent medical care if these severe symptoms arise.