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This product's use requires careful consideration, especially for women. Here are some important safety guidelines and precautions:

• Avoid Additional Hormones: Do not combine this product with extra estrogens, progestins, or estrogen agonist/antagonists. Refer to the Drug Interactions section for more information.
• Serious Side Effects: Using estrogens alone or with progestins can occasionally result in severe side effects. It is crucial to discuss the potential risks and advantages of hormone therapy with your healthcare provider. Estrogens are not intended for the prevention of heart disease or dementia.
• Cancer Risk: Estrogens may increase the likelihood of uterine cancer (endometrial cancer). The component bazedoxifene in this product may help mitigate this risk. Report any unusual vaginal bleeding to your doctor immediately.
• Increased Health Risks: For postmenopausal women, estrogens—whether taken with or without progestins—can elevate the risks of breast and ovarian cancer, stroke, dementia, and severe blood clots. When combined with progestins, there is also an increased risk of heart disease, including heart attacks.
• Dosage and Duration: The likelihood of adverse effects may be influenced by the estrogen dose and the duration of use. This medication should be used at the smallest effective dose and for the shortest period necessary. Regularly consult your doctor, ideally every 3 to 6 months, to determine if continued use is appropriate.
• Long-term Use Monitoring: If you are prescribed this medication for an extended period, ensure regular comprehensive physical examinations, at least annually, as instructed by your healthcare provider.

These guidelines are essential for ensuring your safety and the effectiveness of the treatment.

It's common to experience mild side effects such as stomach upset, nausea, vomiting, bloating, breast tenderness, headaches, or weight changes. These effects usually don't last long, but if they persist or worsen, it's important to consult your healthcare provider.

On the other hand, be aware of more serious side effects that require immediate attention. These include persistent nausea or vomiting, breast lumps, changes in mood or memory, severe abdominal pain, yellowing skin or eyes, dark urine, swelling in the hands, ankles, or feet, increased thirst and urination, and unusual vaginal bleeding. Additionally, this medication can increase blood pressure, so regular monitoring is recommended. Report any significant increases to your healthcare provider.

Rare but severe complications from blood clots may occur, leading to heart attacks, strokes, or clots in the lungs or legs. Seek urgent medical help if you experience chest, jaw, or left arm pain, confusion, pain or swelling in the groin or calf, difficulty speaking, sudden dizziness or fainting, severe headaches, changes in vision, shortness of breath, unusual sweating, or weakness on one side of the body.

Though very rare, severe allergic reactions are possible. Symptoms such as rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing require immediate medical attention. Always reach out to your healthcare provider if you notice any side effects not listed here.