Duavee

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This medication combines conjugated estrogens and bazedoxifene and is specifically designed for women with a uterus to alleviate menopause symptoms such as hot flashes and vaginal dryness. Additionally, it helps prevent osteoporosis after menopause. Conjugated estrogens work by replacing the estrogen that the body no longer produces, thereby reducing menopausal symptoms. Bazedoxifene, a selective estrogen receptor modulator (SERM), mimics estrogen's effects in certain parts of the body to maintain bone density and lower the risk of uterine cancer linked to estrogen use. Typically, the medication is taken orally as one tablet daily. Common side effects may include muscle spasms, nausea, and diarrhea. For individuals experiencing symptoms primarily in the vaginal area, topical products might be a preferable option over oral medications. Always consult healthcare professionals before starting any new treatment.
Our Duavee coupons are free to use. You can print the coupon, email it to yourself, or receive the Duavee coupon via text message. To get your free discount, show the pharmacist your Duavee savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Duavee prices will update based on your prescription needs. Above our Duavee coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Duavee savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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0.45-20MG, Duavee (30 Tablets)

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CVS

$193.54

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$191.57

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$193.05

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Walgreens

$200.91

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$200.95

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Duavee savings card

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$193.54

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Duavee dosage forms

The average cost for 30 Tablets of Duavee at 0.45-20MG is $191.57 with a free coupon. This is 27.14% off the average retail price of $705.96
DosageQuantityPrice fromPer unit
0.45-20MG30 Tablets$191.57$6.39

Duavee Warnings

This document provides essential safety information regarding the use of this medication, highlighting potential risks, precautions, and important instructions. Please read carefully and consult your healthcare provider with any concerns.

  • Blood Clots and Related Complications: The active components in this medication may increase the risk of developing blood clots, which can obstruct blood flow to critical areas such as the legs, lungs, heart, or brain, potentially leading to severe complications like heart attacks or strokes. Individuals with a personal or family history of blood clots, high blood pressure, diabetes, obesity, high cholesterol, lupus, or those who smoke or are using additional estrogen medications should exercise caution.

  • Uterine Cancer Risk: Estrogens in the medication can alter the uterine lining, increasing the risk of endometrial cancer. Bazedoxifene helps mitigate this risk. Women with a healthy uterus, those on estrogen therapy without progestin, or those using estrogen for over a year should take note. Watch for unusual vaginal bleeding and report it to your doctor.

  • Breast and Ovarian Cancer: It remains unclear if this medication affects the risk of breast or ovarian cancer. Regular screenings are advised while using this treatment.

  • Dementia Risk: Postmenopausal individuals aged 65 and above taking estrogen-only therapy may face an increased risk of dementia. Look out for early signs such as memory loss and disorientation. This medication should not be used for dementia prevention.

  • Gallbladder and Liver Concerns: Estrogen medications can elevate the risk of gallbladder issues, particularly in postmenopausal individuals. Report any persistent jaundice or stomach pain to your healthcare provider. Avoid use if you have liver problems.

  • Vision Changes: Rarely, estrogens may cause vision changes due to clots affecting eye blood vessels. Discontinue use and consult your provider if you experience sudden vision loss or migraines.

  • Triglyceride Levels: Estrogen therapy may increase blood triglyceride levels, leading to pancreatitis. Those with a history of high triglycerides should monitor for symptoms like abdominal pain radiating to the back.

  • Thyroid Hormone Levels: Estrogens can alter thyroid hormone levels, particularly affecting individuals with hypothyroidism.

  • Fluid Retention: This medication may cause fluid retention, leading to swelling in extremities. Those with heart failure or kidney issues should be cautious.

  • Worsening of Existing Conditions: Disclose your full medical history, as this medication might exacerbate conditions such as asthma, diabetes, epilepsy, migraines, lupus, hypoparathyroidism, and hereditary angioedema.

Contraindications: Do not use this medication if you have abnormal vaginal bleeding, current or past breast cancer, estrogen-dependent tumors, blood clotting disorders, a history of stroke or heart attack, liver problems, or if you are pregnant. Always consult your healthcare provider if any of these apply to you.

Duavee Side Effects

When taking this medication, you might experience some common side effects. These include stomach upset, nausea, vomiting, bloating, breast tenderness, headache, and weight changes. Some people also report muscle spasms, diarrhea, indigestion, upper stomach pain, throat pain, dizziness, and neck pain. These effects are generally mild and should ease over time. However, if they persist or worsen, it's important to consult your healthcare provider for advice.

In some cases, more serious side effects may occur. These include persistent nausea or vomiting, lumps in the breast, mental or mood changes like depression or memory loss, severe abdominal pain, yellowing of the eyes or skin, dark urine, swelling in the hands, ankles, or feet, increased thirst or urination, and unusual vaginal bleeding. Additionally, this medication can cause a rise in blood pressure, so regular monitoring is advised. Contact your healthcare provider immediately if you experience any of these symptoms.

Rarely, this medication can lead to serious complications such as blood clots. Signs of blood clots may include pain or swelling in the leg, chest pain, trouble breathing, sudden dizziness, severe headaches, sudden vision changes, or weakness on one side of the body. These require urgent medical attention. Although a serious allergic reaction is rare, seek immediate help if you notice symptoms like a rash, itching, swelling, severe dizziness, or trouble breathing.

It's crucial to remain vigilant for any new or worsening symptoms and seek medical advice when needed. While this overview includes many potential side effects, it's not exhaustive. Always communicate openly with your healthcare provider about any concerns regarding your medication.

Duavee Interactions

Duavee (conjugated estrogens / bazedoxifene) can interact with various other drugs and supplements. It is important to inform your doctor and pharmacist about all the medications, vitamins, and supplements you are taking, whether they are prescription or over-the-counter.

Drug Interactions:

  • Potentially Avoidable Combinations: Avoid using Duavee with aromatase inhibitors like Anastrozole, Exemestane, and Letrozole, as well as other estrogen agonist/antagonists such as ospemifene and Raloxifene. Medications like fezolinetant, Fulvestrant, Tamoxifen, and Tranexamic Acid also fall into this category due to potential interactions. Additionally, using Duavee with amifampridine, bupropion, or Donepezil is generally not advised unless necessary.

  • Increased Side Effect Risk: Some drugs, when used with Duavee, may elevate the risk of side effects. These include etoricoxib, Ginseng, Levothyroxine, licorice, and tipranavir. If these combinations are deemed essential, your doctor might adjust the dosage or frequency of administration.

Lab Test Interference: Duavee might affect certain laboratory tests, such as those for metyrapone, blood clotting, and thyroid function, potentially leading to inaccurate results. It is essential to inform lab personnel and all your healthcare providers that you are using Duavee to prevent misinterpretation of test outcomes.

Duavee FAQs
What is the drug Duavee used for?

Duavee is used for the treatment of moderate to severe vasomotor symptoms associated with menopause and for the prevention of postmenopausal osteoporosis in women with an intact uterus.

Duavee was not taken off the market. It is still available, but its availability may vary depending on the region and specific pharmacy stock. If there are concerns about accessing Duavee, it is advisable to consult with a healthcare provider or pharmacist for alternatives or further information.

Weight gain is not listed as a common side effect of Duavee. However, individual responses to medication can vary, and some people may experience changes in weight. If there are concerns about weight changes while taking Duavee, it is advisable to consult with a healthcare provider for personalized advice.

Duavive is a medication used to treat moderate to severe vasomotor symptoms associated with menopause, such as hot flashes. It combines conjugated estrogens with bazedoxifene, which acts as an estrogen agonist/antagonist to help reduce the risk of endometrial hyperplasia that can occur with estrogen use.

Yes, Duavee contains conjugated estrogens. It is a combination medication that includes both conjugated estrogens and bazedoxifene.