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Egrifta SV (tesamorelin) is a medication that carries several important safety considerations. It is essential to understand these risks and precautions before starting treatment. Below are key points for patients and healthcare professionals to review:

• Increased Cancer Risk: This medication can stimulate tumor or cancer cell growth due to its action of releasing growth hormone. It is not suitable for individuals with active cancer or tumors, and those with a history of cancer should use it cautiously, as it may lead to cancer recurrence. Patients with HIV are at an elevated cancer risk and should thoroughly discuss the risks and benefits with their healthcare provider.

• Fluid Retention: Egrifta SV can cause fluid accumulation, potentially resulting in swelling, joint pain, and stiffness. While these symptoms may resolve over time, treatment may need to be discontinued if they persist.

• Blood Sugar Variations: The medication can increase blood sugar levels, raising the risk of developing diabetes. Regular monitoring of blood sugar is recommended, and discontinuation of the drug may be necessary if diabetes develops, particularly for those with a history of diabetes.

• Allergic Reactions: Serious allergic reactions, such as rash, itching, hives, redness, and flushing, can occur. Immediate discontinuation and contacting a healthcare provider are crucial if these symptoms are observed.

• Injection Site Reactions: Common reactions include pain, redness, itching, irritation, and bruising at the injection site. Rotating the injection site may help alleviate these effects.

• Increased Mortality in Severely Ill Patients: Patients undergoing treatment with growth hormone may face a higher risk of death following major surgeries or severe illnesses. If severe illness occurs, discontinuation of Egrifta SV may be advised.

Contraindications: Egrifta SV should not be used under the following conditions, as it poses significant health risks:

• Active cancer or tumor presence.
• Pregnancy or intention to become pregnant.
• Pituitary gland issues, such as tumors or history of surgery.
• History of head injury or radiation treatment to the head.

Patients are advised to consult with their healthcare provider if any of these contraindications apply to them before starting Egrifta SV.

When using this medication, some individuals may experience common side effects such as redness, itching, pain, irritation, or bruising at the injection site. These are generally mild and should not cause alarm, but if they persist or worsen, it's advisable to consult a healthcare provider. Other common effects include muscle aches and joint stiffness, as well as occasional fluid buildup in the body.

In some cases, users may report additional side effects like tingling sensations, rash, vomiting, indigestion, fast or irregular heartbeat, night sweats, muscle stiffness, joint swelling, or carpal tunnel syndrome. While these are less common, they should be monitored, and seeking medical advice is recommended if they occur.

There are rare but serious side effects that require immediate medical attention. These include severe allergic reactions characterized by symptoms such as rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. The medication may also rarely increase the risk of developing a new cancer or cause a previous cancer to return. Additionally, there is a rare possibility of increased blood sugar levels, which can lead to or exacerbate diabetes. If symptoms of high blood sugar, such as increased thirst or urination, are noticed, contact a healthcare professional promptly.

Overall, while many users do not experience serious side effects, staying informed and vigilant is crucial for ensuring safety when using this medication.