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When taking this medication, you might experience mild side effects such as tiredness or hiccups. These are generally not a cause for concern, but if they persist or worsen, it's important to consult with a healthcare professional. Most individuals taking this drug do not experience serious side effects, which is reassuring.

Although rare, a very serious allergic reaction can occur. Be vigilant for symptoms such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. Should you encounter any of these, seeking immediate medical assistance is crucial.

It's important to note that this list does not cover all possible side effects. If you observe any unusual reactions or symptoms not mentioned here, it is advisable to contact your healthcare provider for guidance. Your health and safety are paramount, and prompt communication with a professional can help manage any concerns effectively.

Aprepitant can interact with various medications by altering how they are processed in your body, which can impact their effectiveness. Drugs that can influence the removal of aprepitant include azole antifungals (such as Itraconazole and Ketoconazole), diltiazem, macrolide antibiotics (like Clarithromycin and Erythromycin), Nefazodone, HIV protease inhibitors (such as nelfinavir), rifamycins (including Rifampin and Rifabutin), Ritonavir, St. John's wort, and certain anti-seizure medications (such as Carbamazepine and Phenytoin).

Conversely, aprepitant can modify the way other medications are broken down, potentially affecting their action. Examples of these medications include elacestrant, Flibanserin, lomitapide, and Pimozide.

If you are taking Warfarin, aprepitant may influence its effectiveness, and your doctor should monitor your blood levels closely for two weeks following aprepitant treatment to ensure warfarin is working properly.

Additionally, aprepitant can reduce the effectiveness of hormonal birth control methods, such as pills, patches, or rings, increasing the risk of pregnancy. It is important to consult your doctor or pharmacist about using a reliable backup birth control method during treatment and for one month after the last dose. Inform your doctor if you experience any new spotting or breakthrough bleeding, as these could indicate reduced birth control effectiveness.

Finally, avoid using fosaprepitant concurrently with aprepitant, as they are very similar.