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Experiencing stomach upset, lightheadedness, dizziness, or a sensation of spinning is possible. These symptoms are generally mild, but if they persist or worsen, consult your healthcare provider. While most individuals using this medication do not encounter serious issues, it's important to be aware of potential severe side effects. Notify your healthcare provider immediately if you experience serious symptoms like painful or difficult swallowing, changes in hearing such as ringing in the ears or decreased hearing, joint stiffness, pain, or swelling, or any indications of kidney or liver problems, including changes in urine, loss of appetite, abdominal pain, yellowing of the eyes or skin.

Minocycline, though rarely, can cause increased pressure around the brain, known as intracranial hypertension (IH), particularly in women who are overweight or have had IH previously. Symptoms like severe headaches, vision changes, or persistent nausea and vomiting require urgent medical attention, as there is a risk of permanent vision impairment. Another rare but serious condition is a severe intestinal infection caused by C. difficile, which can occur during or after treatment with this medication. Persistent diarrhea, abdominal pain, or blood in stools should prompt immediate consultation with your healthcare provider. Avoid using anti-diarrhea or opioid products as they may worsen these symptoms.

Additionally, the medication may occasionally lead to oral thrush or yeast infections. Look out for white patches in the mouth or changes in vaginal discharge, and seek medical advice if these appear. Although a severe allergic reaction is uncommon, seek emergency medical help if you experience symptoms such as persistent fever, swollen lymph nodes, rash, severe dizziness, or breathing difficulties. This overview is not exhaustive; for any unlisted effects, contact your healthcare provider for guidance.