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When taking this medication, you may experience some common side effects such as drowsiness, dizziness, dry mouth, nose, or throat, headache, upset stomach, constipation, or trouble sleeping. These effects are usually mild but if they persist or worsen, it is important to inform your healthcare provider.

There are also some serious side effects to be aware of. These include mental or mood changes like confusion or hallucinations, ringing in the ears, difficulty urinating, and vision changes such as blurred or double vision. Should you experience any of these, it is crucial to seek medical advice promptly.

In rare cases, very serious side effects can occur, including a fast or irregular heartbeat and seizures. Immediate medical attention is needed if you encounter these symptoms. Additionally, although a severe allergic reaction is rare, be alert for signs such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. These require urgent medical care.

It's important to know that this list is not exhaustive. If you notice any other unusual effects, reach out to your healthcare provider for advice.

Some medications and products can interact with this drug. Be cautious if you're using skin-applied antihistamines like diphenhydramine cream, ointment, or spray. Combining this drug with MAO inhibitors can lead to a serious, potentially fatal interaction. It is important to avoid MAO inhibitors such as isocarboxazid, linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine while taking this medication. Most MAO inhibitors should also be avoided for two weeks before starting this medication. Consult your doctor for guidance on when to begin or stop this treatment.

Inform your healthcare provider if you're taking any other medications that cause drowsiness. These include opioid pain relievers or cough suppressants like codeine or Hydrocodone, alcohol, marijuana, sleep or anxiety medications such as Alprazolam, Lorazepam, or Zolpidem, muscle relaxants like Carisoprodol or Cyclobenzaprine, and other antihistamines such as Cetirizine or diphenhydramine. Always check the labels of your medications, including allergy or cold remedies, as they may contain ingredients that induce drowsiness. Consult your pharmacist about how to use these products safely.

Additionally, this medication might affect the results of certain medical or lab tests, such as brain scans for Parkinson's disease, urine drug screenings, and allergy skin tests, potentially leading to false results. Ensure that all medical personnel and your doctors are aware that you are using this drug.