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Individuals who should avoid taking flaxseed include those with bowel obstructions or narrowing of the esophagus or intestines, as flaxseed can exacerbate these conditions. People with hormone-sensitive cancers or conditions, such as breast or ovarian cancer, should also be cautious, as flaxseed may act like estrogen in the body. Additionally, those with allergies to flaxseed or flaxseed oil should avoid it. Pregnant or breastfeeding women should consult a healthcare provider before using flaxseed. It's important for anyone considering flaxseed supplementation to discuss it with their healthcare provider, especially if they have existing health conditions or are taking other medications.

Flaxseed can interfere with certain medications, including blood thinners like warfarin, as it may increase the risk of bleeding. It can also affect the absorption of oral medications due to its high fiber content. Additionally, flaxseed may interact with medications for diabetes by affecting blood sugar levels. It's important for individuals to consult with their healthcare provider before adding flaxseed to their diet if they are taking any medications.

Flaxseed can have several negative effects, particularly when consumed in large amounts. These may include gastrointestinal issues such as bloating, gas, and diarrhea. It can also interfere with the absorption of certain medications due to its high fiber content. Additionally, flaxseed contains phytoestrogens, which may affect hormone levels, so individuals with hormone-sensitive conditions should use caution. It's important to consume flaxseed with plenty of water to prevent digestive blockages. As with any supplement, it's advisable to consult a healthcare provider before adding flaxseed to the diet, especially for those with pre-existing health conditions or those who are pregnant or breastfeeding.