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Pioglitazone

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Pioglitazone is a diabetes drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Pioglitazone is used either alone or in combination with other diabetes medications (such as metformin or a sulfonylurea such as glyburide). Talk to your doctor about the risks and benefits of pioglitazone.
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WarningsPioglitazone Side EffectsInteractionsFAQs

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15MG, Pioglitazone (30 Tablets)

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CVS

$19.23

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$5.27

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$8.00

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$12.57

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$52.64

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Warnings

Pioglitazone may rarely cause or worsen a certain heart problem (heart failure). Tell your doctor right away if you notice any symptoms of heart failure, including: shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain. This medication is not recommended for people with certain types of heart failure. Before using this medication, tell your doctor if you have heart failure.

Pioglitazone Side Effects

Sore throat, muscle pain, weight gain, or tooth problems may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating, signs of liver disease (such as nausea/vomiting that doesn't stop, dark urine, yellowing eyes/skin, stomach/abdominal pain). Pioglitazone does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. Symptoms of high blood sugar (hyperglycemia) include increased thirst/urination. If these symptoms occur, tell your doctor right away. Your doctor may need to adjust your diabetes medication, exercise program, or diet. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs. Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Pioglitazone FAQs
What is the main side effect of pioglitazone?

The main side effect of pioglitazone is fluid retention, which can lead to edema. This can be particularly concerning for individuals with heart failure, as it may exacerbate their condition. Other common side effects include weight gain and an increased risk of bone fractures. It is important for patients to discuss potential side effects with their healthcare provider.

Metformin and pioglitazone are not the same thing. They are both medications used to treat type 2 diabetes, but they belong to different classes and work in different ways. Metformin is a biguanide that primarily decreases glucose production in the liver and improves insulin sensitivity. Pioglitazone is a thiazolidinedione that also improves insulin sensitivity but works by acting on different cellular pathways.

The major concern with pioglitazone is its potential association with an increased risk of bladder cancer, especially with long-term use. Additionally, it may cause or exacerbate heart failure, and it can lead to weight gain and edema. Regular monitoring and evaluation by a healthcare provider are recommended for patients taking this medication.

Doctors may still prescribe metformin, as it remains a common and effective treatment for type 2 diabetes. However, there have been some concerns about impurities found in certain batches of metformin, specifically NDMA (N-nitrosodimethylamine), which is a potential carcinogen. This has led to recalls of specific lots of the medication. Additionally, some patients may experience side effects or have contraindications that make other medications more suitable. It is important for patients to discuss their treatment options with their healthcare provider to determine the best course of action for their individual needs.

The choice between Jardiance and Actos depends on the individual's specific medical condition, health profile, and treatment goals. Jardiance (empagliflozin) is an SGLT2 inhibitor, while Actos (pioglitazone) is a thiazolidinedione. Jardiance is often used for its benefits in reducing cardiovascular risk and aiding in weight loss, whereas Actos may be chosen for its effectiveness in improving insulin sensitivity. A healthcare provider should evaluate the patient's overall health, potential side effects, and any other medications being taken to determine the most appropriate treatment.

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