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Pioglitazone has the potential to induce or exacerbate a rare heart condition known as heart failure. It is important to promptly inform your healthcare provider if you experience any of the following symptoms indicative of heart failure:

• Difficulty breathing
• Swelling of the ankles or feet
• Unexplained fatigue
• Sudden or unusual weight gain

This medication is generally not advised for individuals with specific forms of heart failure. Prior to commencing treatment with this medication, it is essential to discuss any history of heart failure with your doctor.

You might experience mild effects such as a sore throat, muscle pain, weight gain, or tooth issues. These usually aren't serious, but if they persist or worsen, contact your healthcare provider. While most people using this medication do not experience severe side effects, it's important to be aware of them. Serious side effects include vision changes like blurred vision, bone fractures, reddish urine, urgent urination, painful urination, or signs of liver problems such as persistent nausea or vomiting, dark urine, yellowing of the eyes or skin, and stomach pain.

Pioglitazone typically does not cause low blood sugar (hypoglycemia). However, combining it with other diabetes medications can increase this risk, especially if you drink alcohol, exercise intensely, or skip meals. To prevent low blood sugar, maintain a regular eating schedule. Symptoms to watch for include sudden sweating, shaking, a fast heartbeat, hunger, blurred vision, dizziness, or tingling in your hands or feet. Keep glucose tablets or gel handy, or have quick sugar sources like candy or juice available.

High blood sugar symptoms include increased thirst and urination. If these occur, contact your healthcare provider promptly as your medication, diet, or exercise plan may need adjustments. Although rare, serious allergic reactions can occur, marked by a rash, itching, swelling (especially of the face, tongue, or throat), dizziness, or difficulty breathing. If you experience these, seek medical attention immediately. Remember, this list doesn't cover all possible side effects, so if you notice anything unusual, consult your healthcare provider.