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Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), carries certain risks and requires specific precautions during use. The following points outline essential safety information:

• Increased Risk of Heart Attack or Stroke: Ibuprofen may rarely elevate the risk of heart attack or stroke, which can occur at any time during treatment. The likelihood is heightened with prolonged use, particularly in older adults or individuals with existing heart conditions or risk factors like smoking, family history, high blood pressure, or diabetes. Avoid using ibuprofen immediately before or after coronary artery bypass graft (CABG) surgery.

• Potential for Gastrointestinal Bleeding: This medication may rarely cause severe bleeding in the stomach or intestines, possibly without warning. Older adults are more susceptible to this risk.

• Serious Side Effects: Discontinue use and seek immediate medical attention if you experience any of the following symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, unilateral body weakness, speech difficulties, or sudden changes in vision.

• Consultation with Healthcare Professionals: It is important to discuss the potential benefits and risks of using ibuprofen with your doctor or pharmacist to ensure safe and effective use.

By adhering to these guidelines, patients and healthcare providers can work together to manage the risks associated with ibuprofen.

When taking this medication, you may experience some mild side effects such as an upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These are generally not serious and often resolve on their own. However, if these effects persist or worsen, it's important to contact your healthcare provider.

It's also possible for this medication to cause an increase in blood pressure, so regular monitoring is advised. Notify your healthcare provider if you notice consistently high readings. In some cases, more serious side effects can occur. These include easy bruising or bleeding, changes in hearing like ringing in the ears, mood or mental changes, an unexplained stiff neck, or signs of kidney issues such as changes in urination. Vision changes and symptoms of heart failure, like swelling in the ankles or feet, unusual tiredness, or sudden weight gain, also warrant immediate medical attention.

A rare but severe risk associated with this medication is liver disease, which can be life-threatening. Seek immediate medical assistance if you experience persistent nausea or vomiting, loss of appetite, dark urine, stomach or abdominal pain, or yellowing of the eyes or skin. Furthermore, although uncommon, serious allergic reactions can occur. Symptoms include fever, swollen lymph nodes, rash, severe itching or swelling, especially of the face, tongue, or throat, severe dizziness, and difficulty breathing. Immediate medical help should be sought if these occur. If you encounter any side effects not mentioned, promptly consult with your healthcare provider.

Certain medications can interact with this drug, leading to potential health risks. These include aliskiren, ACE inhibitors like captopril and lisinopril, angiotensin II receptor blockers such as losartan and valsartan, cidofovir, corticosteroids like prednisone, lithium, and diuretics, often referred to as "water pills," such as furosemide. Additionally, this medication could heighten bleeding risks if taken alongside other drugs that also promote bleeding. This includes anti-platelet medications like clopidogrel and anticoagulants, commonly known as "blood thinners," such as dabigatran, enoxaparin, and warfarin.

It is important to scrutinize all prescription and over-the-counter medication labels since many contain painkillers or fever reducers, such as aspirin or NSAIDs like celecoxib, ketorolac, or naproxen, which are similar to ibuprofen and may elevate the likelihood of side effects if used concurrently. However, if you have been advised by your healthcare provider to take low-dose aspirin (typically 81-162 milligrams daily) for heart attack or stroke prevention, continue doing so unless instructed otherwise by your doctor. It's worth noting that regular ibuprofen use might reduce aspirin's effectiveness in preventing heart attacks or strokes. Discuss with your doctor the possibility of using alternative medications, such as acetaminophen, for pain or fever management. If ibuprofen is necessary, consult your doctor about the timing of aspirin intake, ideally taking ibuprofen at least 8 hours before or 2 hours after your aspirin. Do not alter your aspirin dosage or any medication regimen without professional medical advice.