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The safety and warning information for this medication is essential to ensure your well-being. Please review the following details and consult your healthcare provider if you have any questions or concerns.

• Overdose Risks: Taking an excessive amount of colchicine can be life-threatening, with both accidental and intentional overdoses reported in adults and children. Always follow your healthcare provider's instructions and keep colchicine out of children's reach. Early signs of an overdose include stomach pain, nausea, vomiting, and diarrhea, which can cause dehydration. If you suspect an overdose, immediately contact the Poison Control Center at 1-800-222-1222 or seek urgent medical assistance.

• Blood Cell Production: Colchicine may impair your body's ability to produce new blood cells, even at prescribed doses. This can become serious if not detected early. Ensure regular laboratory tests are conducted and inform your provider if you experience symptoms like bleeding, bruising, fevers, or persistent fatigue.

• Drug and Food Interactions: Colchicine can interact with various medications, potentially increasing its levels in your body to dangerous levels. Interacting substances include calcium channel blockers, digoxin (Lanoxin), statins, certain antifungals, protease inhibitors for HIV, and cyclosporine (Neoral or Sandimmune). Provide your healthcare providers with a complete list of medications you take, even if colchicine is used occasionally, to adjust dosages as necessary.

• Nerve and Muscle Toxicity: Long-term use of colchicine may lead to nerve or muscle toxicity, including a condition called rhabdomyolysis, where damaged muscle tissue releases harmful proteins into your bloodstream. The risk is higher if you are on statins, fibrates, or cyclosporine. Seek medical help immediately if you experience muscle pain, dark urine, or difficulty moving. Symptoms generally resolve within a week after stopping colchicine, though it may take longer in some cases. Risks are elevated for long-term users, individuals with poor kidney function, older adults, and those taking statins, fibrates, or cyclosporine.

• Contraindications: Individuals with kidney or liver disease, especially when combined with interacting medications, should not use colchicine due to potential severe health risks. Consult your healthcare provider if you have these conditions before starting colchicine.

Always discuss any concerns or questions with your healthcare provider to ensure safe and effective use of colchicine.

When taking this medication, some individuals may experience common side effects such as diarrhea and nausea. These effects are usually mild, but if they persist or worsen, it is advisable to consult a healthcare provider. Tiredness, headache, and throat pain have also been reported, and while they are generally not severe, any concerns should be discussed with a medical professional.

There are also more serious side effects that, although rare, require immediate medical attention. These include allergic reactions with symptoms like rash, itching, hives, and swelling of the face, lips, tongue, or throat. Signs of infection, such as fever, chills, persistent sore throat, or difficulty urinating, also necessitate urgent care. Muscle-related issues can present as unusual weakness or fatigue, muscle pain, and changes in urine color or volume. Additionally, unusual bleeding or bruising, as well as pain, tingling, or numbness in the hands or feet, should prompt immediate medical consultation.

While a very serious allergic reaction is rare, it is important to seek medical help right away if you experience severe dizziness or trouble breathing. Always be vigilant about any unexpected changes in your health and communicate them to your healthcare provider.

Colchicine's effectiveness and safety can be influenced by other medications that affect its elimination from the body. This may change how colchicine works or increase the likelihood of significant side effects. Medications such as atazanavir, azole antifungals (like itraconazole and ketoconazole), diltiazem, certain antibiotics (including clarithromycin and erythromycin), ritonavir, telithromycin, and verapamil are known to interact with colchicine.

Additionally, colchicine can sometimes cause a rare but serious muscle condition known as rhabdomyolysis, which may lead to severe kidney issues. The risk of developing rhabdomyolysis may be heightened when colchicine is combined with other drugs that have similar side effects, such as digoxin, gemfibrozil, pravastatin, and simvastatin.

It's important not to use any other product containing colchicine while taking this medication. Furthermore, colchicine may interfere with certain laboratory tests, potentially leading to incorrect results. Inform all healthcare providers and lab technicians that you are using colchicine.