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Glucosamine is a natural compound commonly used as a dietary supplement to support joint health, particularly in individuals with osteoarthritis. While generally considered safe for most people, certain individuals should exercise caution or avoid glucosamine supplementation due to specific health concerns.

Individuals with shellfish allergies should be aware that many glucosamine products are derived from the shells of shrimp, lobster, and crabs. Although the risk of an allergic reaction is considered low, it is advisable for those with shellfish allergies to consult a healthcare provider before using glucosamine supplements.

People with asthma may experience worsening of their condition when taking glucosamine. Therefore, individuals with asthma should use glucosamine cautiously and under medical supervision.

There is some concern that glucosamine might raise intraocular pressure, potentially worsening glaucoma. Individuals with glaucoma should consult their healthcare provider before starting glucosamine supplements.

For individuals with diabetes, there was previously concern that glucosamine might increase blood sugar levels. However, most research indicates that glucosamine does not significantly affect blood sugar control. Nonetheless, it is advisable for those with diabetes to monitor their blood sugar levels closely when initiating glucosamine supplementation.

Pregnant and breastfeeding women should avoid using glucosamine supplements due to insufficient reliable information regarding their safety during these periods.

As with any supplement, it is important to consult a healthcare provider before starting glucosamine, especially if you have existing health conditions or are taking other medications.