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This medication comes with critical safety warnings that must be understood thoroughly to ensure safe usage. It carries significant risks, including potential for addiction, misuse, and serious breathing problems. Below are important considerations for its use:

• Risk of Abuse and Addiction: This medication has a high potential for abuse, which can lead to addiction, overdose, or even death. Follow the prescribed dosage strictly and avoid taking more than directed. It's crucial to use the smallest effective dose for the shortest period necessary.

• Breathing Problems: There is a heightened risk of severe breathing difficulties, especially when starting the medication, changing doses, or combining it with alcohol or other sedatives. These can be life-threatening. If you experience slow or shallow breathing, severe drowsiness, or difficulty waking up, seek immediate medical attention.

• Interactions with Other Substances: Combining this medication with alcohol, benzodiazepines, opioids, or other drugs causing drowsiness can result in dangerous side effects, including respiratory failure. Avoid alcohol and consult your healthcare provider about possible drug interactions.

• Emergency Measures: In case of overdose or accidental ingestion, access emergency medical services immediately. Symptoms of overdose may include extreme dizziness, difficulty breathing, or inability to stay awake.

• Special Populations: Pregnant women should avoid using this medication as it may increase the risk of birth defects and withdrawal symptoms in newborns. It's especially important to minimize use to the smallest effective dose for the shortest duration possible.

• Children and Adolescents: This medication should not be administered to children under 12 years of age due to the risk of serious side effects like life-threatening respiratory issues.

• Pre-existing Conditions: Patients with conditions such as severe asthma, respiratory depression, or stomach blockage should not use this medication. It is also contraindicated if you're taking or have recently taken monoamine oxidase inhibitors (MAOIs).

• Storage and Security: Keep this medication in a secure place to prevent theft, misuse, or accidental ingestion by others.

Consult with your healthcare provider for any concerns and follow their guidance meticulously to ensure safe use of this medication.

When taking this medication, you may experience some common side effects, such as drowsiness, dizziness, lightheadedness, and nausea. These effects are usually mild and manageable, but if they persist or worsen, it's important to consult your healthcare provider. Additionally, vomiting and constipation may occur. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

In rare cases, more serious side effects might occur. These include interrupted breathing during sleep (sleep apnea), mental or mood changes like hallucinations, fast or irregular heartbeat, and trouble urinating. If you notice any of these symptoms, seek medical advice promptly. A very serious side effect is a seizure, which requires immediate medical attention.

Codeine, found in this medication, can be converted into morphine in the body. For some individuals, this conversion happens more rapidly and completely, increasing the risk of severe side effects such as slow or shallow breathing, severe drowsiness, confusion, or difficulty waking up. If you experience any of these, seek emergency medical help immediately.

Allergic reactions, though rare, are serious and require urgent care. Symptoms include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. If you experience signs of an allergic reaction, contact emergency services without delay. Always report any side effects to your healthcare provider to ensure your safety.

Codeine/guaifenesin can interact with a variety of medications and substances. It's important to inform your doctor and pharmacist about all other medications or supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products. This will help prevent potential interactions.

Some products known to interact with codeine/guaifenesin include cimetidine, naltrexone, and samidorphan. Additionally, taking this medication with other substances that cause drowsiness or breathing issues, like opioid pain relievers (e.g., morphine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (e.g., alprazolam, lorazepam), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or antihistamines (e.g., cetirizine, diphenhydramine), can increase the likelihood of severe side effects such as slow or shallow breathing and intense drowsiness or dizziness.

It's also crucial to check the labels of all your medications, especially allergy or cough-and-cold products, as they might contain ingredients that induce drowsiness. Consult your pharmacist on the safe use of these products.

Furthermore, certain medications can affect how codeine/guaifenesin is metabolized by your body, altering its effectiveness. These include azole antifungals (e.g., ketoconazole), bupropion, fluoxetine, macrolide antibiotics (e.g., erythromycin), paroxetine, quinidine, rifamycins (e.g., rifabutin, rifampin), ritonavir, and some seizure medications (e.g., carbamazepine, phenytoin).

Lastly, be aware that this medication may interfere with certain lab tests, potentially leading to false results. Always inform lab personnel and your healthcare providers that you are using this drug.