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The following safety information outlines important warnings and precautions associated with the use of this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Drowsiness: This medication can cause significant drowsiness, which may impair your ability to concentrate, think clearly, or react quickly. The likelihood and severity of this effect increase if you are over 65, consume alcohol, or use other sedative medications, such as opioids, benzodiazepines, or sleep aids. Avoid driving or operating heavy machinery until you understand how the medication affects you.

• Serotonin Syndrome: A rare but serious condition known as serotonin syndrome can occur if there is an excess of serotonin in the brain. This risk is heightened if you have taken monoamine oxidase inhibitors (MAOIs) within 14 days prior to starting this medication or if you are using other drugs that increase serotonin levels.

• Exacerbation of Certain Health Conditions: Inform your primary care physician and pharmacist about any existing medical conditions before beginning treatment. This medication may not be suitable if you have heart disease, high blood pressure, respiratory issues (such as emphysema or chronic bronchitis), a cough producing significant mucus, thyroid disorders, diabetes, glaucoma, or urinary complications.

• Overdose Risk: This medication includes dextromethorphan (a cough suppressant), phenylephrine (a decongestant), and triprolidine (an antihistamine). These components are also present in various other over-the-counter products, increasing the risk of accidental overdose if these products are used concurrently.

Additionally, this medication should not be used if you are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) within the last 14 days, as this may result in severe health risks. Always consult your healthcare provider for guidance tailored to your health status.

When taking this medication, you may experience some common side effects such as drowsiness, dizziness, headache, blurred vision, upset stomach, nausea, constipation, or a dry mouth, nose, or throat. These effects are usually mild, but if they persist or worsen, it’s important to consult your healthcare provider. Drinking plenty of fluids can help alleviate some of these symptoms, particularly the dryness and thickening of mucus in your lungs. To manage dry mouth, consider using sugarless gum or candy, ice chips, or saliva substitutes.

In some cases, individuals may feel nervous, restless, or have trouble sleeping. While these are less common, if they occur and cause discomfort, it’s advisable to reach out to a healthcare professional.

There are also more serious, albeit rare, side effects that require immediate medical attention. These include mental changes such as confusion or hallucinations, ringing in the ears, tremors, difficulty urinating, unexplained weakness, easy bruising or bleeding, and irregular heartbeat. Additionally, symptoms of serotonin syndrome, such as a rapid heart rate, excessive sweating, muscle stiffness, high fever, or severe confusion, necessitate urgent care.

A very serious allergic reaction to this medication is uncommon but can occur. If you notice a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or breathing difficulties, seek medical help immediately. Always communicate with your healthcare provider about any other effects you notice that are not listed here.

Taking this medication alongside certain MAO inhibitors can lead to a severe, potentially life-threatening interaction. Avoid using MAO inhibitors like isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine while on this medication. It's important not to take most MAO inhibitors within two weeks before or after this treatment. Consult your doctor about the appropriate timing for starting or stopping these medications.

Additionally, some products can interact with this drug, including skin-applied antihistamines (e.g., diphenhydramine cream, ointment, or spray) and rolapitant. Inform your doctor or pharmacist if you are using other substances that cause drowsiness, such as opioid painkillers or cough suppressants (like codeine or hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as alprazolam, lorazepam, or zolpidem), muscle relaxants (like carisoprodol or cyclobenzaprine), and other antihistamines (like cetirizine or diphenhydramine).

Be sure to check the labels on all your medications, including those for allergies or cough-and-cold, as they might contain ingredients that induce drowsiness. Discuss with your pharmacist how to use these products safely.

This medication can also affect the results of certain medical or lab tests, such as brain scans for Parkinson's disease, urine drug screening tests, and allergy skin tests, potentially causing inaccurate outcomes. Ensure that all lab personnel and healthcare providers are informed that you are using this medication.