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This document outlines important safety information regarding the use of Humulin N (human insulin). It is crucial to review these details carefully and discuss any concerns with your healthcare provider.

• Sharing of Pens and Needles: Do not share Humulin N pens, syringes, or needles with anyone to avoid the risk of transmitting infections or contracting serious diseases.

• Low Blood Sugar (Hypoglycemia): Humulin N, whether used alone or with other diabetes medications, can cause hypoglycemia, which may be life-threatening. Symptoms include shakiness, hunger, nervousness, fast heartbeat, sweating, confusion, weakness, or increased sleepiness. Keep a source of sugar nearby to manage symptoms should they occur. Discuss with your healthcare provider if hypoglycemic episodes are frequent. Factors increasing risk include dietary changes, alcohol consumption, other diabetes medications, age over 65, liver or kidney issues, and incorrect insulin administration.

• Severe Allergic Reactions: Although rare, Humulin N can trigger serious allergic reactions. Seek emergency medical attention if you experience breathing difficulties, a severe rash with fever, or swelling of the face, mouth, or throat.

• Low Blood Potassium Levels: Using Humulin N may lead to decreased potassium levels, posing health risks. This risk is heightened if you use medications that lower potassium levels, such as certain laxatives or diuretics. Regular potassium level monitoring and potential medication adjustments by your healthcare provider may be necessary.

• Drug Interaction with Thiazolidinediones: If you are taking Thiazolidinediones like pioglitazone or rosiglitazone, your healthcare provider will closely monitor you as combining these with insulin can cause fluid retention and exacerbate heart failure.

Please ensure you are informed about these risks and precautions to safely manage your health while using Humulin N.

When taking this medication, it's important to be aware of potential side effects. Common side effects include reactions at the injection site, such as pain, redness, or irritation, as well as weight gain. These are usually mild, and if they persist or worsen, consulting a healthcare provider is advisable. Other frequent side effects may involve swelling in the legs, headaches, and the development of fat deposits under the skin.

Low blood sugar, or hypoglycemia, is another possible side effect. It may cause symptoms like sweating, shaking, a fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. To manage hypoglycemia, it's helpful to carry glucose tablets or gel, or consume a quick source of sugar like candy or fruit juice. Maintaining a regular meal schedule can help prevent low blood sugar episodes.

More serious side effects, though rare, should not be ignored. These include severe hypoglycemia, which can lead to unconsciousness or seizures, and severe allergic reactions characterized by rash, itching, swelling, or difficulty breathing. Additionally, dangerously low potassium levels may present as muscle cramps, weakness, irregular heartbeat, or constipation. If any of these severe symptoms occur, seeking immediate medical attention is crucial.

While this is a comprehensive overview, it's not exhaustive. If you experience any other unusual effects, reaching out to a healthcare provider is recommended.