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When considering Hyrimoz for the treatment of Crohn's disease or ulcerative colitis, it's important to be aware of several potential risks associated with its use:

Serious Infections: Hyrimoz can lower your immune system's ability to fight infections, increasing the risk of serious infections that may lead to hospitalization or death. These include tuberculosis (TB), invasive fungal infections, and other opportunistic infections. Before starting Hyrimoz, your doctor should test you for latent TB and monitor you for signs of infection during and after treatment. If a serious infection develops, Hyrimoz should be discontinued.

Malignancies: There is an increased risk of certain types of cancer, including lymphoma and other malignancies, some of which have been fatal, in patients treated with TNF blockers like Hyrimoz. This risk is particularly noted in children, adolescents, and young adults with inflammatory bowel disease. Discuss the potential risks and benefits with your doctor before starting treatment.

Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis and angioedema, have been reported. If you experience symptoms such as hives, difficulty breathing, or swelling of the face, eyes, lips, or mouth, seek immediate medical attention and discontinue Hyrimoz.

Hepatitis B Virus Reactivation: In patients who are carriers of hepatitis B virus (HBV), Hyrimoz may increase the risk of HBV reactivation, which can be severe or fatal. Your doctor should evaluate you for HBV infection before initiating treatment and monitor you during and after therapy. If HBV reactivation occurs, Hyrimoz should be stopped, and appropriate antiviral therapy should be initiated.

Neurologic Reactions: Rare cases of new onset or worsening of demyelinating diseases, such as multiple sclerosis and Guillain-Barré syndrome, have been associated with TNF blockers. If you develop symptoms like vision problems, weakness in your arms or legs, or numbness or tingling, inform your doctor promptly.

Hematological Reactions: Rare reports of blood disorders, including decreased blood cell counts, have been observed. Seek immediate medical attention if you experience symptoms such as persistent fever, bruising, bleeding, or pallor.

Heart Failure: Worsening or new onset congestive heart failure has been reported with TNF blockers. If you have heart failure, use Hyrimoz with caution and under close monitoring.

Autoimmunity: Treatment with Hyrimoz may lead to the formation of autoantibodies and, in rare cases, the development of a lupus-like syndrome. If you develop symptoms such as chest discomfort, shortness of breath, joint pain, or a rash on your cheeks or arms that worsens with sun exposure, contact your doctor.

Immunizations: Avoid live vaccines while using Hyrimoz. Ensure that all immunizations are up to date before starting treatment.

It's crucial to discuss these risks with your healthcare provider to determine if Hyrimoz is appropriate for your condition.

When starting Hyrimoz for Crohn's disease or ulcerative colitis, it's important to be aware of potential interactions with other medications and treatments:

• Biologic Medications: Combining Hyrimoz with other biologic disease-modifying antirheumatic drugs (DMARDs), such as anakinra or abatacept, is not recommended. This combination can increase the risk of serious infections without providing additional benefits.

• Live Vaccines: Avoid receiving live vaccines while on Hyrimoz, as they may lead to infections. Live vaccines include those for measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

• Immunosuppressants: Using Hyrimoz with other immunosuppressive medications, such as Methotrexate or corticosteroids, may increase the risk of infections.

• Medications Metabolized by CYP450 Enzymes: Hyrimoz may affect the metabolism of drugs processed by the cytochrome P450 system, such as Warfarin, Cyclosporine, or Theophylline. Monitoring and possible dose adjustments of these medications may be necessary.

Before starting Hyrimoz, inform your healthcare provider about all medications and supplements you are taking to ensure safe and effective treatment.