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This medication is used to treat moderate to severe plaque psoriasis. Tildrakizumab belongs to a class of drugs known as monoclonal antibodies. It works by blocking a certain natural substance in your body (interleukin-23) that may lead to the overgrowth of skin cells and redness/swelling seen in plaque psoriasis. Tildrakizumab can help lessen the symptoms of plaque psoriasis, including red, scaly, itchy patches of skin.