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Estrogen treatments, whether used alone or in combination with another hormone like progestin, may infrequently lead to very serious side effects. It is important to have a thorough discussion with your healthcare provider about the potential benefits and risks of hormone therapy. Estrogens are not recommended for the prevention of heart disease or dementia.

Key Safety Information:

• Cancer Risk: Estrogen use can increase the risk of uterine cancer (endometrial cancer). Taking progestin as prescribed by your doctor can mitigate this risk. Report any unusual vaginal bleeding to your healthcare provider immediately.

• Postmenopausal Risks: For postmenopausal women, the use of estrogens, with or without progestin, may elevate the risk of breast or ovarian cancer, stroke, dementia, and severe blood clots. When combined with progestin, there is also an increased risk of heart disease, including heart attacks.

• Dosage and Duration: The likelihood of serious side effects may be influenced by the estrogen dosage and the duration of use. It is advised to use the lowest effective dose for the shortest necessary duration. Regular consultations with your doctor, typically every 3 to 6 months, are essential to evaluate the ongoing need for this medication.

• Long-term Use: If long-term use is necessary, ensure you undergo regular comprehensive physical examinations, such as annually, as directed by your healthcare provider.

By following these guidelines, you can help manage the risks associated with estrogen therapy. Always maintain open communication with your healthcare provider about your treatment plan.

You might experience some mild side effects from this medication, such as nausea, vomiting, bloating, diarrhea, breast tenderness, headaches, or weight changes. These are generally not serious, but if they persist or worsen, it's important to seek advice from a healthcare professional.

While most users do not encounter severe reactions, be vigilant for any serious side effects, including mental or mood changes like depression, lumps in the breast, unusual vaginal bleeding, or increased vaginal irritation. Additionally, watch for signs of liver issues, such as persistent nausea, loss of appetite, stomach pain, yellowing of the skin or eyes, and dark urine. Other concerning symptoms include swelling in hands, ankles, or feet, and signs of high blood sugar, such as increased thirst or urination.

This medication can rarely cause serious blood clot problems, which could lead to heart attacks, strokes, or clots in the lungs or legs. Seek immediate medical attention if you experience shortness of breath, chest pain, unusual sweating, sudden dizziness, or severe headaches. Also, be alert for pain or swelling in the calf, sudden vision changes, or trouble speaking.

Although extremely rare, a serious allergic reaction is possible. Symptoms like rash, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing require urgent medical care. If you notice any side effects not mentioned here, it's advisable to consult your healthcare provider.