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Estrogen treatments, whether used alone or in combination with another hormone like progestin, can occasionally lead to very serious side effects. It is important to have a thorough discussion of the risks and benefits of hormone therapy with your healthcare provider.

Key Safety Information:

• Cancer Risk: Estrogens can raise the risk of developing uterine (endometrial) cancer. Taking progestin as prescribed can help lower this risk. Report any unusual vaginal bleeding to your doctor immediately.
• Other Risks for Postmenopausal Women: The use of estrogens, with or without progestin, can increase the risk of breast and ovarian cancer, stroke, dementia, and serious blood clots. When combined with progestin, there is also an increased risk of heart disease, including heart attacks.
• Usage Guidelines: The risk of serious side effects is influenced by the estrogen dosage and duration of use. It is recommended to use the lowest effective dose for the shortest time necessary. Regular consultation with your doctor is essential to determine the ongoing need for this medication, ideally every 3 to 6 months.
• Long-term Use: If long-term use is necessary, schedule regular comprehensive physical examinations, typically once a year, as advised by your healthcare provider.

Please note that estrogens should not be used for preventing heart disease or dementia. Always consult your healthcare provider for personalized advice and follow their recommendations closely.

When taking this medication, you may experience mild side effects such as nausea, vomiting, bloating, diarrhea, breast tenderness, headache, or changes in weight. These are generally not a cause for concern but should be monitored. If these symptoms persist or worsen, it's important to consult your healthcare provider.

More serious side effects are less common but require immediate attention. These include mental or mood changes, such as increased depression, breast lumps, unusual vaginal bleeding patterns, or new vaginal irritation. Additionally, signs of liver issues like persistent nausea, loss of appetite, abdominal pain, jaundice, or dark urine should be reported promptly.

A rare but serious risk associated with this medication is the formation of blood clots, which can lead to life-threatening conditions like heart attacks or strokes. Be vigilant for symptoms such as shortness of breath, chest pain, sudden dizziness, severe headaches, or swelling and warmth in the legs, and seek medical assistance immediately if they occur.

Allergic reactions to this medication are very rare but can be severe. Symptoms may include rash, swelling, severe dizziness, or difficulty breathing. Immediate medical help is crucial if these symptoms develop.

Always keep in touch with your healthcare provider about any new or unusual symptoms you experience while on this medication. This summary includes the most important side effects, but it is not exhaustive. For any concerns, reach out to your healthcare provider for guidance.