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When considering the use of this medication, it is important to be aware of certain safety considerations, especially for older adults with dementia. This medication may pose a slightly increased risk of serious, potentially fatal side effects, such as:

• Stroke
• Heart failure
• Fast or irregular heartbeat
• Pneumonia

It is crucial to note that this medication is not approved for addressing dementia-related behavior issues. Therefore, it is essential to discuss with your healthcare provider the potential risks and benefits, as well as explore other effective and potentially safer treatment options for these conditions. Always consult your doctor to ensure a comprehensive understanding of your treatment plan.

Paliperidone can cause several side effects, ranging from mild to severe. Commonly, you might experience drowsiness, dizziness, lightheadedness, restlessness, weight gain, or pain and swelling at the injection site. These mild effects are generally manageable and often do not require medical attention, but if they persist or worsen, it is advisable to consult a healthcare professional. To reduce dizziness and lightheadedness, rise slowly from sitting or lying positions to minimize the risk of falling.

More serious side effects include difficulty swallowing, shaking, muscle spasms, and interrupted breathing during sleep. Immediate medical attention is necessary for very serious side effects such as fainting, severe dizziness, slow heartbeat, or seizures. A rare but concerning condition called tardive dyskinesia may occur, characterized by unusual or uncontrolled movements, particularly of the face and limbs. Another serious condition, neuroleptic malignant syndrome (NMS), requires urgent medical care if symptoms like fever, muscle stiffness, or severe confusion arise.

Paliperidone may affect blood sugar levels, potentially causing or worsening diabetes. Monitoring blood sugar levels is crucial for individuals with diabetes, and adjustments to medications or lifestyle may be necessary. Weight gain and increased cholesterol levels are also possible, which could elevate the risk of heart disease. Rarely, this medication may increase prolactin hormone levels, leading to various symptoms in both females and males, including reproductive issues. In rare instances, males may experience a prolonged erection lasting over four hours, which demands immediate medical intervention to prevent long-term complications.

Finally, while allergic reactions to Paliperidone are rare, symptoms like rash, swelling, or trouble breathing require prompt medical attention. Always inform your healthcare provider about any unusual effects you experience while taking this medication.

When taking Invega Hafyera (paliperidone), it's important to be aware of potential drug interactions. Inform your doctor and pharmacist about all medications and supplements you are using, whether they are prescription, over-the-counter, or herbal.

Certain medications should not be combined with Invega Hafyera. These include metoclopramide, bepridil, bromopride, cisapride, dronedarone, mesoridazine, pimozide, piperaquine, sparfloxacin, terfenadine, thioridazine, and ziprasidone. Your doctor might advise against using these medications with Invega Hafyera or may adjust your treatment plan.

Additionally, some drugs can interact with Invega Hafyera and may require careful monitoring or dose adjustments if used together. These include medications like amiodarone, chlorpromazine, disopyramide, dofetilide, moxifloxacin, quinidine, sotalol, procainamide, and others. These drugs can affect heart rhythm (QT prolongation), which necessitates caution.

Furthermore, medications such as paroxetine might increase the risk of side effects when used with Invega Hafyera, but in some cases, combining them may provide the best therapeutic outcome. Your healthcare provider will consider the benefits and risks, possibly adjusting doses accordingly.

Lastly, be cautious with products that cause drowsiness, such as opioid pain relievers, alcohol, cannabis, sleep or anxiety medications, muscle relaxants, and certain antihistamines. Check medication labels for ingredients that may cause drowsiness, and consult your pharmacist for safe usage.