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It is critical to fully understand the safety information and warnings associated with the use of Jolessa (levonorgestrel/ethinyl estradiol), a combined oral contraceptive. The following points will guide you through the potential risks, precautions, and special instructions for specific populations.

• Smoking and Heart Risks: If you smoke cigarettes, especially if you are over 35 years old, using Jolessa can significantly increase your risk of serious heart problems, including stroke, heart attack, and blood clots. Discuss safer contraceptive options with your healthcare provider if you are a smoker.

• Blood Clots and Stroke: Jolessa heightens the risk of blood clots that could lead to conditions such as pulmonary embolism, deep vein thrombosis, stroke, and heart attack. Immediate medical attention is necessary if symptoms of a blood clot arise. This risk is notably higher for women over 35, those with high blood pressure, diabetes, obesity, or who are using high estrogen doses.

• Cancer Risks: There is a potential increased risk of breast and cervical cancer with prolonged use of Jolessa. Those with a history of breast cancer should avoid this medication. Regular screenings and reporting any unusual symptoms to your healthcare provider are crucial.

• Liver Concerns: Jolessa may cause liver problems, although this is rare. Do not use this medication if you have existing liver issues. Contact your healthcare provider immediately if you experience symptoms indicative of liver problems.

• Metabolic Effects: Jolessa can elevate blood sugar and triglyceride levels. Patients with diabetes should monitor their blood sugar closely and report any significant changes to their healthcare provider.

• Blood Pressure: The medication might increase blood pressure. Regular monitoring is advised, and those with uncontrollable high blood pressure should avoid using Jolessa.

• Headaches: While headaches are common, any severe or new migraines should be evaluated by a healthcare provider.

• Irregular Bleeding: Breakthrough bleeding and spotting can occur, particularly in the initial months of use. Report any unusual bleeding patterns to your healthcare provider.

• Depression: Monitor for any signs of depression or worsening symptoms, and consult your provider if these occur.

• Gallbladder Issues: The risk of gallbladder disease might be increased, particularly in those with a history of such conditions.

• Hereditary Angioedema: Those with this genetic condition should be cautious, as Jolessa can trigger swelling attacks.

• Drug Interactions: Jolessa's effectiveness can be reduced by certain medications, including some used to treat epilepsy and hepatitis C. Inform your healthcare provider about all medications you are taking.

• Contraindications: Avoid using Jolessa if you have a high risk of blood clots, a history of cardiovascular issues, certain liver diseases, or if you are pregnant. Discuss with your healthcare provider if you are over 35 and smoke, have migraines with aura, or have other contraindicating conditions.

In the event of an overdose or severe reaction, seek emergency medical assistance immediately. Always consult your healthcare provider for guidance tailored to your specific health needs and conditions.

When taking this medication, you may experience some common side effects, which are generally mild. These include nausea, vomiting, headaches, bloating, and breast tenderness. Fluid retention may lead to swelling of the ankles or feet, and some individuals might notice weight changes. Spotting or light vaginal bleeding between periods is also common, particularly in the first few months of use. If these effects persist or worsen, it's important to consult with your healthcare provider.

More serious side effects, though less common, should be addressed promptly. These include significant mood changes, such as depression, and lumps in the breast. Severe stomach or abdominal pain, unusual changes in menstrual bleeding, dark urine, and yellowing of the eyes or skin are also concerning and warrant immediate medical attention.

Rare but severe side effects include the risk of blood clots, which can result in heart attacks, strokes, or clots in the lungs or legs. Symptoms like chest pain, confusion, sudden dizziness, pain or swelling in the calf or groin, trouble speaking, or sudden vision changes need urgent medical care. Additionally, severe allergic reactions, while rare, require immediate help, especially if you notice symptoms like rash, itching, swelling of the face or throat, severe dizziness, or breathing difficulties.

In some cases, you may also experience acne, period cramps, mood swings, weight gain, migraines, or a feeling of depression. It's advised to monitor your blood pressure regularly, as this medication can cause an increase. If you experience any unusual symptoms not listed here, or if your symptoms concern you, contacting your healthcare provider is recommended.