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This vaccine is used to help prevent smallpox or monkeypox infection. Smallpox and monkeypox are caused by a certain type of virus (orthopox virus). This vaccine contains live viruses that have been weakened. It works by increasing the body's natural defense (immunity) against the viruses. This vaccine is recommended for people at high risk for the infection. Those at high risk include certain lab, health care, or public health workers, and people who have been exposed to someone infected with an orthopox virus. Vaccines may not fully protect everyone who receives them.