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Lamotrigine is a medication that requires careful attention to potential side effects, particularly the risk of serious skin rashes. Below are essential safety and warning details to be aware of when taking this medication:

• Risk of Skin Rashes: Serious and potentially fatal skin rashes have been reported, especially in children. The risk increases with high initial doses, rapid dose escalation, or concurrent use with certain anti-seizure medications like valproic acid or divalproex. Most severe rashes occur within 2 to 8 weeks of starting treatment.

• Allergic Reactions: Seek immediate medical attention if you experience any skin rash or signs of a severe allergic reaction. Symptoms include hives, fever, swollen lymph nodes, severe dizziness, painful sores in the mouth or around the eyes, facial/tongue/throat swelling, breathing difficulties, or liver problems (e.g., persistent stomach/abdominal pain, ongoing nausea/vomiting, dark urine, or yellowing eyes/skin).

• Medical Guidance: Consult your doctor if a rash develops. They will advise whether to discontinue lamotrigine. Note that even after stopping the medication, a rash may still progress to a life-threatening condition or lead to permanent damage.

These precautions are crucial for ensuring safe use of lamotrigine. Always follow your healthcare provider’s instructions and report any adverse effects promptly.

Common side effects:

• Dizziness
• Drowsiness
• Headache
• Vomiting
• Upset stomach

Serious side effects:

• Depression
• Suicidal thoughts or behaviors
• Mood disorders
• Fainting
• Irregular heartbeat
• Unusual bruising or bleeding
• Stiff neck
• Vision issues
• Loss of coordination
• Muscle pain or weakness
• Signs of kidney problems

Interactions with high risk of serious adverse effects and should be avoided:

• Dofetilide

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Orlistat
• Hormonal birth control (such as pills, patches)
• Estrogens
• Phenobarbital
• Primidone
• Valproic acid
• Rifampin
• Ritonavir
• Alcohol
• Marijuana (cannabis)
• Antihistamines (such as cetirizine, diphenhydramine)
• Drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem)
• Muscle relaxants
• Opioid pain relievers (such as codeine)