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When taking this medication, it's important to be aware of potential serious skin rashes, which in rare cases can be fatal. These rashes occur more frequently in children than in adults and are more likely if the medication is started at a high dose, if the dose is increased too quickly, or if taken in combination with certain other anti-seizure medications like valproic acid or divalproex. Serious rashes have most commonly appeared within 2 to 8 weeks after beginning treatment with lamotrigine, but they can occur at any time during use.

Here are important precautions and actions to consider:

• Seek immediate medical attention if you develop any type of skin rash or signs of a severe allergic reaction. These signs include hives, fever, swollen lymph nodes, severe dizziness, painful sores in the mouth or around the eyes, facial/tongue/throat swelling, breathing difficulties, or symptoms of liver problems such as persistent stomach pain, ongoing nausea or vomiting, dark urine, or yellowing of the eyes or skin.
• Your healthcare provider will guide you on whether to discontinue use of lamotrigine.
• Be aware that even after stopping the medication, a rash can still become life-threatening or leave permanent scars or other complications.

Always follow your healthcare professional's instructions and report any concerning symptoms immediately.

When taking this medication, some individuals may experience dizziness, drowsiness, headache, vomiting, or an upset stomach. These side effects are generally mild, but if they persist or worsen, it is important to inform your healthcare provider. While many people do not encounter serious side effects, it is crucial to be aware of potential mental health changes. A few individuals using anticonvulsants for conditions like seizures, bipolar disorder, or pain may experience depression, suicidal thoughts, or other mood changes. Immediate medical attention should be sought if any unusual shifts in mood, thoughts, or behavior occur.

Serious side effects, although rare, require urgent medical assistance. These include fainting, irregular or pounding heartbeat, unexplained bruising or bleeding, stiff neck, vision disturbances, loss of coordination, muscle pain or weakness, and signs of kidney issues such as changes in urination. It is important to monitor for these symptoms and seek help promptly if they arise. This overview does not encompass all potential side effects. If you notice any other unusual symptoms, please consult your healthcare provider for further advice.

Certain medications can interact with this drug, affecting its effectiveness and your health. Notably, drugs such as dofetilide and orlistat may interact with it. Additionally, other medications can impact how lamotrigine is cleared from your body, potentially altering its effectiveness. These include hormonal birth control methods (like pills and patches), estrogens, some anti-seizure drugs (including phenobarbital, primidone, and valproic acid), as well as rifampin and ritonavir. Your healthcare provider might need to adjust your lamotrigine dose if you are taking these medications.

It's important to note that this drug may reduce the effectiveness of hormonal birth control, which could lead to pregnancy. It's advisable to discuss with your doctor or pharmacist whether you should use an additional form of reliable birth control while on this medication. If you experience any new spotting or breakthrough bleeding, inform your doctor, as these could indicate that your birth control isn't working properly.

Additionally, inform your healthcare provider if you consume other products that might cause drowsiness, such as alcohol, cannabis, antihistamines (e.g., cetirizine, diphenhydramine), sleep or anxiety medications (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, or opioid pain relievers (e.g., codeine). When using over-the-counter products like allergy or cough-and-cold medications, check their labels for ingredients that could induce drowsiness, and consult your pharmacist on their safe use.

Lastly, be aware that this drug may interfere with certain laboratory tests, such as urine drug screenings, potentially leading to incorrect results. Ensure that all your healthcare providers and laboratory personnel are informed that you are taking this medication.