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This medication comes with important safety warnings that need to be carefully considered. Please review the following information and consult with your healthcare provider if you have any questions or concerns:

• Pregnancy Warning: This medication must not be used during pregnancy due to the risk of serious harm to an unborn child. Female patients must use reliable birth control before, during, and for one month after treatment. Discuss with your doctor the appropriate forms of birth control to use. A pregnancy test is required before starting treatment. If you become pregnant or suspect you might be, contact your healthcare provider immediately. Participation in the Ambrisentan REMS program is required to ensure maximum safety for females who can become pregnant.

• Fluid Retention: This medication can cause fluid retention, which may lead to swelling or shortness of breath. The risk is heightened if you have a history of heart failure, as it can exacerbate your condition. Notify your healthcare provider if you have any heart issues before beginning treatment. Seek medical advice if you experience symptoms such as shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, fatigue, or an inability to exercise.

• Anemia Risk: There is a potential for this medication to cause a decrease in hemoglobin levels, leading to anemia. This typically occurs within the first few weeks of treatment but usually stabilizes. If you experience symptoms of anemia, such as fatigue or shortness of breath, inform your healthcare provider.

• Contraindications: Do not use this medication if you are currently pregnant or have been diagnosed with idiopathic pulmonary fibrosis (IPF), as it may cause serious health complications.

Your safety is a priority, and understanding these risks will help ensure the effectiveness of your treatment. Always consult with your healthcare provider for personalized medical advice.

When taking this medication, you might experience some mild side effects, such as a stuffy or runny nose, flushing, or swelling in the arms or legs. These effects are generally not serious, but if they persist or worsen, it's advisable to consult your healthcare provider for guidance. Additionally, some individuals might encounter sinus infections or inflammation.

While rare, there are more serious side effects to be aware of. If you experience symptoms such as a fast or irregular heartbeat, extreme tiredness, swelling in the ankles or feet, or sudden weight gain, you should seek medical attention immediately. These could indicate fluid buildup in the body, which is a serious condition.

Liver-related side effects, although uncommon, are significant. Signs include persistent nausea or vomiting, loss of appetite, severe stomach pain, dark urine, or yellowing of the skin or eyes. Immediate medical attention is crucial if these symptoms occur, as they may indicate liver injury.

Allergic reactions to this medication are rare but can be severe. Be alert for symptoms like rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing, and seek urgent medical help if they occur. Always monitor for any other unusual effects and consult your healthcare provider if necessary.