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This medication comes with important safety warnings that you should carefully consider. It is crucial to consult with your healthcare provider for any concerns or questions regarding its use.

• Liver Function Changes: While standard doses of Livdelzi (seladelpar) at 10 mg daily typically do not cause significant liver enzyme increases, higher doses (50 mg daily) have been associated with elevated liver enzyme levels, indicating potential liver stress or damage. These levels generally normalize after discontinuing the medication. Be cautious if you have a history of liver issues or are taking higher doses.

• Bone Fractures: There have been reports of fractures in individuals using Livdelzi (seladelpar) during clinical trials, occurring within the first 3 to 12 months of treatment. Those with a history of fractures, osteoporosis, or those using the medication long-term should be particularly vigilant.

• Biliary Obstruction: Livdelzi (seladelpar) should not be used by individuals with a complete biliary obstruction, characterized by symptoms such as upper right abdominal pain and jaundice. Immediate consultation with your healthcare provider is advised if these symptoms appear, as discontinuation of the medication may be necessary during evaluation and treatment.

No specific contraindications are available for this medication, but always consult your healthcare provider for personalized advice.

When taking this medication, some individuals may experience mild side effects such as headaches, nausea, bloating, dizziness, and stomach pain. These are common and usually not concerning, but if they persist or worsen, it's advisable to consult with your healthcare provider for further guidance.

In some cases, patients have reported additional side effects like skin rash, hair loss, cough, anemia, and indigestion. While these are less common, they should be monitored, and any persistence or severity should be discussed with a healthcare professional.

There are rare but serious side effects that require immediate medical attention. These include symptoms of liver problems, such as persistent nausea or vomiting, loss of appetite, stomach pain, yellowing of the skin or eyes, and dark urine. Additionally, signs of bone fractures, severe allergic reactions such as rash and difficulty breathing, or unusual changes in mood or sleep patterns should be addressed by seeking urgent medical care.

Overall, while the majority of people do not experience severe side effects with this medication, it is important to remain vigilant and consult your healthcare provider if you experience any concerning symptoms.