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Voclosporin is used in combination with other medications to treat a certain kidney disorder (lupus nephritis). Lupus nephritis is an immune disorder where certain proteins in your own body attack and cause damage to the kidneys. Symptoms may include blood/protein in the urine, high blood pressure, and poor kidney function. Voclosporin belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help decrease damage to your kidneys.