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This document outlines critical safety information and warnings regarding the use of norethindrone. It is crucial to understand these precautions and consult your healthcare provider if you have any questions or concerns.

• Medication Interactions: Inform your healthcare provider or pharmacist about all medications and supplements you are currently taking prior to initiating norethindrone. This ensures they can assess any potential interactions with other substances.

• Ectopic Pregnancy or Ovarian Cyst: There is a slight possibility of an ectopic pregnancy (pregnancy outside the uterus) occurring while on norethindrone. This condition can be severe. Seek immediate medical attention if you experience symptoms such as cramping or pain in the lower abdomen or shoulder area.

• Irregular Vaginal Bleeding: Experiencing irregular vaginal bleeding is a common side effect of progestin-only pills (POPs) like norethindrone. While often benign, it can occasionally indicate a more serious issue, such as an infection or cancer. Consult your healthcare provider if you have concerns, and if there is an absence of vaginal bleeding, confirm with your provider whether you are pregnant.

• Possible Cancer Risk: Some research indicates that combination birth control pills may elevate the risk of breast or ovarian cancer. The risk associated with norethindrone or other POPs is not yet fully understood. Discuss any worries about cancer risk with your healthcare provider.

Additionally, certain contraindications signal when norethindrone should not be used due to potential severe health risks:

• Pregnancy: Avoid use if pregnant.
• Breast Cancer: Do not use if breast cancer is confirmed or suspected.
• Undiagnosed Vaginal Bleeding: If experiencing unexplained bleeding between periods, refrain from use until diagnosed by a healthcare provider.
• Liver Tumors: Avoid if you have benign or cancerous liver tumors.
• Acute Liver Disease: Do not use in cases of sudden liver disease.

Always prioritize your safety by discussing any of these conditions with your healthcare provider before starting norethindrone.

When taking this medication, some individuals may experience common side effects such as nausea, vomiting, headaches, bloating, or breast tenderness. Additionally, weight gain, irregular periods, or spotting between periods are possible. These effects are generally mild and should not cause alarm; however, if they persist or worsen, consulting a healthcare provider is advisable.

Occasionally, users may encounter dizziness, which, like the common side effects, is typically not severe. Nevertheless, if dizziness becomes concerning, it should be discussed with a medical professional. More concerning symptoms, such as lumps in the breast, significant mood changes, severe stomach or abdominal pain, dark urine, or yellowing of the eyes or skin, should be addressed immediately with a healthcare provider, as they may indicate more serious issues.

In rare cases, this medication may lead to severe complications such as an ectopic pregnancy, which is characterized by stomach pain and spotting. This requires urgent medical attention. Additionally, while a very serious allergic reaction is rare, symptoms like rash, swelling, severe dizziness, or trouble breathing require immediate medical help. Always be vigilant to any unusual symptoms and seek medical advice if needed.