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When using Sulfamylon (mafenide), it's crucial to be aware of several important safety warnings. Please review the following information carefully and consult your healthcare provider if you have any questions or concerns:

• Risk of Low Red Blood Cell Counts and Abnormal Clotting: Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency should consult their healthcare provider before using this medication. Although rare, there have been reports of life-threatening changes in red blood cell counts such as anemia, and abnormal clotting or bleeding associated with G6PD deficiency.

• Severe Allergic Reactions: Sulfamylon (mafenide) contains sulfite and sulfa components, which can trigger allergic reactions in some individuals. Immediate medical attention is needed if symptoms like hives, swelling, or difficulty breathing occur. Individuals with known allergies to sulfites or sulfa, and those with asthma, should inform their healthcare provider and pharmacist prior to use. It's advisable for asthmatics to keep a rescue inhaler accessible when starting this medication, as sulfite allergies are more prevalent in this group.

• Increased Blood Acidity (Acidosis): This medication may lead to elevated acid levels in the blood, particularly in patients with kidney issues or those applying it to extensive burn areas. Healthcare providers may recommend regular blood tests to monitor this condition. Immediate medical advice is necessary if you experience accelerated breathing, a potential sign of acidosis.

• Fungal Growth Risk: While Sulfamylon (mafenide) inhibits bacterial growth, it may encourage fungal growth on the treated areas. Though rarely severe, any worsening of wound symptoms such as increased pain, redness, or swelling should be reported to your healthcare provider.

For further clarification or if you experience any adverse symptoms, contact your healthcare provider promptly.

Common side effects:

• pain
• burning sensation

Less common but important to monitor:

• fatigue
• paleness
• abnormal clotting and bleeding
• blood in the urine or stool
• chest pain
• difficulty breathing
• leg pain or swelling
• bruising
• high acid levels in the blood
• fast breathing
• dizziness
• nausea

Serious side effects:

• serious allergic reaction
• rash
• hives
• swelling of the face, lips, tongue, or throat
• severe dizziness
• difficulty breathing

When using mafenide acetate, it's important to be aware of potential interactions with other medications:

• Local Anesthetics: Combining mafenide acetate with certain local anesthetics, such as Lidocaine or prilocaine, may increase the risk of a condition called methemoglobinemia, which affects the blood's ability to carry oxygen. Patients should be closely monitored for signs of this condition if these medications are used together.

• Antidiabetic Medications: Mafenide acetate may enhance the blood sugar-lowering effects of antidiabetic drugs like Glipizide, Glyburide, and Metformin. This can increase the risk of low blood sugar (hypoglycemia). Patients with diabetes should have their blood sugar levels monitored closely during treatment.

• Methenamine: Using mafenide acetate with methenamine, a medication used to prevent urinary tract infections, is not recommended. This combination can lead to the formation of crystals in the urine, potentially causing kidney problems.

• Dapsone: Combining mafenide acetate with dapsone, a medication used to treat certain infections, may increase the risk of methemoglobinemia. Patients should be monitored for symptoms of this condition if these drugs are used together.

• Carbonic Anhydrase Inhibitors: Both mafenide acetate and carbonic anhydrase inhibitors (used to treat conditions like glaucoma) can cause metabolic acidosis, a condition where the blood becomes too acidic. Using them together may increase this risk. Patients should be monitored for signs of acidosis if these medications are combined.

It's essential to inform your healthcare provider about all medications you're currently taking, including over-the-counter drugs and supplements, to avoid potential interactions.