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The following safety information outlines crucial warnings associated with the use of Sulfamylon (mafenide). It is vital to understand these risks and to consult your healthcare provider to address any specific concerns.

• Risk of Low Red Blood Cell Counts and Abnormal Clotting: Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency should consult their healthcare provider before using Sulfamylon (mafenide). Although exceedingly rare, this medication may lead to life-threatening changes in red blood cell counts, such as anemia, and abnormal clotting or bleeding.

• Severe Allergic Reactions: Sulfamylon (mafenide) contains sulfite and sulfa components, which may trigger allergic reactions in susceptible individuals. Symptoms of an allergic reaction include hives, swelling, and difficulty breathing. Immediate medical attention is required if these symptoms occur. Inform your healthcare provider and pharmacist of any known allergies before starting this medication. Those with asthma should keep their rescue inhaler accessible, as sulfite allergies are more prevalent among asthmatics.

• Increased Acid Levels in the Blood (Acidosis): This medication can elevate acid levels in the blood, particularly in individuals with kidney issues or when applied extensively to large burn areas. Your healthcare provider may recommend blood tests to monitor this condition. Rapid breathing can be a sign of acidosis; notify your provider immediately if this occurs.

• Potential for Fungal Growth: Sulfamylon (mafenide) inhibits bacterial growth, which can occasionally allow fungi to proliferate in treated areas. While typically not severe, it is important to contact your healthcare provider if you notice worsening symptoms, such as increased pain, redness, or swelling at the wound site.

Please ensure you discuss any pre-existing conditions or concerns with your healthcare provider before using Sulfamylon (mafenide) to ensure safe and effective use of the medication.

When taking this medication, some individuals may experience mild side effects such as pain or a burning sensation at the site of application. These effects are usually temporary and should not cause concern unless they persist or worsen, in which case you should consult your healthcare provider.

In some cases, users may experience other side effects, such as a low red blood cell count, which can lead to tiredness and paleness. Additionally, abnormal clotting or bleeding can occur, presenting as blood in the urine or stool, chest pain, trouble breathing, or pain and swelling in the leg. If you notice any bruising or other unusual symptoms, seek medical advice promptly.

There is a risk of a severe allergic reaction, though it is rare. Symptoms can include a rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. High acid levels in the blood may also occur, causing fast breathing, dizziness, nausea, and fatigue. If you experience any of these serious side effects, it is crucial to get medical assistance immediately.

Always remain vigilant for any other symptoms not listed here and consult with your healthcare provider if you have concerns about any new or unusual effects while using this medication.