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The following safety information outlines crucial warnings associated with the use of Sulfamylon (mafenide). It is vital to understand these risks and to consult your healthcare provider to address any specific concerns.

• Risk of Low Red Blood Cell Counts and Abnormal Clotting: Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency should consult their healthcare provider before using Sulfamylon (mafenide). Although exceedingly rare, this medication may lead to life-threatening changes in red blood cell counts, such as anemia, and abnormal clotting or bleeding.

• Severe Allergic Reactions: Sulfamylon (mafenide) contains sulfite and sulfa components, which may trigger allergic reactions in susceptible individuals. Symptoms of an allergic reaction include hives, swelling, and difficulty breathing. Immediate medical attention is required if these symptoms occur. Inform your healthcare provider and pharmacist of any known allergies before starting this medication. Those with asthma should keep their rescue inhaler accessible, as sulfite allergies are more prevalent among asthmatics.

• Increased Acid Levels in the Blood (Acidosis): This medication can elevate acid levels in the blood, particularly in individuals with kidney issues or when applied extensively to large burn areas. Your healthcare provider may recommend blood tests to monitor this condition. Rapid breathing can be a sign of acidosis; notify your provider immediately if this occurs.

• Potential for Fungal Growth: Sulfamylon (mafenide) inhibits bacterial growth, which can occasionally allow fungi to proliferate in treated areas. While typically not severe, it is important to contact your healthcare provider if you notice worsening symptoms, such as increased pain, redness, or swelling at the wound site.

Please ensure you discuss any pre-existing conditions or concerns with your healthcare provider before using Sulfamylon (mafenide) to ensure safe and effective use of the medication.

Sulfamylon, also known as mafenide acetate, is a topical medication used to prevent and treat infections in burn wounds. While it is applied directly to the skin, it can be absorbed into the bloodstream, potentially leading to interactions with other medications.

One notable interaction occurs with dichlorphenamide, a medication used to treat certain types of glaucoma and periodic paralysis. Both Sulfamylon and dichlorphenamide can cause metabolic acidosis, a condition where the blood becomes too acidic. Using these medications together may increase the risk of developing this condition. Therefore, if you are prescribed both, your healthcare provider will closely monitor your acid-base balance to ensure your safety.

Additionally, Sulfamylon may interact with allogeneic cultured keratinocytes and fibroblasts, which are types of skin grafts used in burn treatment. The medication can reduce the viability of these grafts, potentially affecting the healing process. If you are receiving such treatments, your healthcare provider will consider this interaction when planning your care.

It's also important to note that Sulfamylon can cause metabolic acidosis on its own, especially in individuals with kidney or lung problems, or those with extensive burns. Symptoms of metabolic acidosis include rapid breathing, confusion, and fatigue. If you experience any of these symptoms while using Sulfamylon, contact your healthcare provider immediately.

Always inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions. Regular monitoring and open communication with your healthcare team can help manage and mitigate any risks associated with medication interactions.