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Mesna, also known by the brand name Mesnex, is a medication that helps prevent bleeding in the bladder, a condition called hemorrhagic cystitis, which can occur in individuals undergoing chemotherapy with ifosfamide. It is sometimes used off-label for those receiving cyclophosphamide. Mesna acts as a protective agent by reducing the harmful effects of a byproduct formed when the body processes ifosfamide, without affecting the drug's cancer-fighting abilities. Mesna is typically administered in three doses, spaced 2 to 4 hours apart, on the day of chemotherapy. This can be given as three injections or one injection followed by two oral doses. Common side effects include nausea and vomiting. Mesna is available in both generic and brand-name forms. Always consult with your healthcare provider for personalized medical advice and before starting any new treatment.