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Mesna

Mesna Coupons & Discount Card – Guaranteed Prices from $608.85

generic Mesnex

Mesna, also known by the brand name Mesnex, is a medication that helps prevent bleeding in the bladder, a condition called hemorrhagic cystitis, which can occur in individuals undergoing chemotherapy with ifosfamide. It is sometimes used off-label for those receiving cyclophosphamide. Mesna acts as a protective agent by reducing the harmful effects of a byproduct formed when the body processes ifosfamide, without affecting the drug's cancer-fighting abilities. Mesna is typically administered in three doses, spaced 2 to 4 hours apart, on the day of chemotherapy. This can be given as three injections or one injection followed by two oral doses. Common side effects include nausea and vomiting. Mesna is available in both generic and brand-name forms. Always consult with your healthcare provider for personalized medical advice and before starting any new treatment.
Our coupons are free to use. Before paying, show the pharmacist your Mesna savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Mesna prices will update based on your prescription needs. Above our Mesna coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Mesna at the lowest price with our prescription discount card.
Mesna WarningsMesna Side EffectsMesna InteractionsFAQs

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400MG, Mesna (30 Tablets)

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CVS

$981.36

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$608.85

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$668.93

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$756.38

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$2118.44

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Walgreens

$608.85

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015995

LHKDT252193

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DR33

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Mesna dosage forms

The average cost for 30 Tablets of Mesna (generic Mesnex) at 400MG is $683.81 with a free coupon. This is 29.10% off the average retail price of $2349.9
DosageQuantityPrice fromPer unit
400MG30 Tablets$683.81$22.79

Mesna Warnings

The following safety information outlines critical warnings and precautions for mesna (Mesnex) usage. Please review these details thoroughly and discuss any concerns with your healthcare provider.

  • Severe Allergic Reactions: Although rare, mesna (Mesnex) can trigger life-threatening allergic responses, even if previously tolerated. Seek emergency medical assistance if you experience symptoms such as fever, dizziness, rapid heartbeat, breathing difficulties, hives, swelling, nausea, vomiting, or joint and muscle pain. This risk is heightened if you are allergic to benzyl alcohol, other inactive components in mesna (Mesnex), or amifostine (Ethyol).

  • Serious Skin Reactions: Mesna (Mesnex) can occasionally lead to severe skin reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome or Stevens-Johnson syndrome (SJS). If you develop a rash with blisters, itching, hives, skin pain, swelling, peeling, or sores in the skin or mouth, or flushed skin, stop using mesna (Mesnex) and seek immediate medical care.

  • Interference with Lab Tests: Mesna (Mesnex) may temporarily affect certain laboratory tests. It can cause false-positive results for urinary ketones or vitamin C and false-negative results for blood tests related to muscle breakdown or kidney issues. Inform your healthcare team about your use of this medication prior to undergoing any laboratory tests.

  • Contraindications: Do not use mesna (Mesnex) if you have a known allergy to the drug or any of its inactive ingredients, including benzyl alcohol. Consult your healthcare provider if you fall into this category before using this medication.

Mesna Side Effects

Common side effects:

  • nausea
  • vomiting
  • constipation
  • loss of appetite
  • diarrhea
  • headache
  • dizziness
  • drowsiness
  • flu-like symptoms
  • sore throat
  • cough

Less common but important to monitor:

  • decrease in blood cell counts
  • fatigue
  • fever
  • weakness
  • belly pain
  • sweating
  • hair loss
  • confusion
  • anxiety
  • trouble sleeping
  • reactions at the injection site

Serious side effects:

  • chest pain
  • fast heartbeat
  • swelling of the ankles or feet
  • muscle weakness
  • low potassium levels
  • severe allergic reaction
  • fever
  • swollen lymph nodes
  • rash
  • severe dizziness
  • trouble breathing
  • serious skin reactions
  • rash with blisters
  • skin peeling
  • sores

Mesna Interactions

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Warfarin
Mesna FAQs
What is the drug mesna used for?

Mesna is used as a protective agent to reduce the risk of hemorrhagic cystitis, a side effect associated with certain chemotherapy drugs like cyclophosphamide and ifosfamide. It works by binding to toxic metabolites in the bladder, thereby preventing damage to the bladder lining.

Mesna is not considered chemotherapy. It is a medication used to protect the bladder from the harmful effects of certain chemotherapy drugs, such as ifosfamide and cyclophosphamide. Mesna works by binding to toxic metabolites in the urine, reducing the risk of bladder irritation and bleeding.

Mesna is given with cyclophosphamide to protect the bladder from the toxic effects of acrolein, a metabolite of cyclophosphamide. Acrolein can cause hemorrhagic cystitis, and mesna helps to neutralize this metabolite, reducing the risk of bladder irritation and bleeding.

Mesna is not classified as a hazardous drug. It is used to protect the bladder from the harmful effects of certain chemotherapy drugs, such as ifosfamide and cyclophosphamide. While it is not considered hazardous, it should still be handled according to standard safety protocols for medications.

The antidote for cyclophosphamide toxicity, specifically to prevent hemorrhagic cystitis, is Mesna (sodium 2-mercaptoethane sulfonate). Mesna binds to the toxic metabolites of cyclophosphamide in the urinary tract, reducing the risk of bladder damage.

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