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Methylphenidate is a medication used for specific medical conditions, but it carries certain risks and requires caution in its use. Below is a summary of important safety information and warnings related to its use.

• Misuse and Dependence Risk: Methylphenidate can be habit-forming. Misuse, such as taking it in a way not prescribed, can lead to serious side effects, including a rapid heartbeat, high blood pressure, aggressive behavior, and self-harm thoughts. Individuals with a history of substance or alcohol use disorders should use this medication with caution. Do not exceed the prescribed dose, and consult your healthcare provider if you have concerns.

• Serious Heart Issues: Methylphenidate may cause heart-related problems, including sudden death, stroke, and heart attack, even at usual doses. It can also increase blood pressure and heart rate. Notify your healthcare provider if you have a history of heart problems. Seek medical help if you experience fainting, chest pain during physical activity, or an irregular heartbeat.

• Behavioral or Mental Changes: This medication can cause changes in mood or behavior, such as hallucinations and mania, especially in individuals with a history of mental health conditions. If you notice any new or worsening mood-related symptoms, contact your healthcare provider immediately.

• Prolonged Erection: Rarely, prolonged and painful erections may occur, which could require medical intervention. If an erection lasts more than four hours, discontinue use and seek medical attention.

• Blood Circulation Issues: Methylphenidate may be associated with Raynaud's phenomenon, which affects blood flow to the fingers and toes, causing them to feel cold or numb. Notify your provider if you experience these symptoms, as dosage adjustments or alternative treatments may be necessary.

• Growth Delay in Children: Stimulants like methylphenidate can temporarily slow growth in height and weight in children. Healthcare providers will monitor growth, and adjustments to treatment may be needed if growth delays are suspected.

• Serotonin Syndrome Risk: Combining methylphenidate with other medications that affect serotonin levels, like certain antidepressants, can lead to serotonin syndrome, a potentially life-threatening condition. Be aware of symptoms such as rapid heart rate, sweating, muscle stiffness, and confusion, and seek immediate medical help if they occur.

• Drug Interactions: Methylphenidate can interact with various medications, including blood pressure medicines and MAOIs, potentially leading to severe side effects. Discuss all medications and supplements you are taking with your healthcare provider before starting methylphenidate.

• Contraindications: This medication should not be used if you have severe allergies to methylphenidate, have used an MAOI in the last 14 days, have certain inherited sugar digestion issues, or in specific conditions like marked anxiety, glaucoma, motor tics, or a family history of Tourette syndrome.

Always consult your healthcare provider for personalized medical advice and before making any changes to your medication regimen.

When taking this medication, some individuals may experience mild side effects such as nervousness, trouble sleeping, headache, dizziness, nausea, vomiting, loss of appetite, weight loss, dry mouth, stomach pain, anxiety, and irritability. These effects are generally not serious, but if they persist or worsen, it is advisable to consult with a healthcare provider.

Additionally, this medication may raise blood pressure, so regular monitoring is recommended. If you experience a racing heart or increased sweating, contact your healthcare provider. While serious side effects are rare, they require immediate medical attention. These include signs of blood flow issues in the fingers or toes, rapid or irregular heartbeat, mental health changes like aggression or mood swings, uncontrolled muscle movements, vision changes, or slow healing sores.

Very serious side effects necessitate urgent medical assistance and include fainting, seizures, symptoms of a heart attack or stroke, and severe allergic reactions such as rash, swelling, or breathing difficulties. Rarely, males might experience a painful or prolonged erection lasting over four hours; this requires prompt medical intervention to prevent long-term issues. If any unusual symptoms occur, it is important to seek medical advice promptly.

When taking Methylphenidate ER, it's important to be aware of potential interactions with other medications. Avoid using it with MAO inhibitors such as isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine, as this combination can lead to a serious, potentially fatal reaction. If you are using MAO inhibitors, you should not start Methylphenidate ER until two weeks after stopping the MAO inhibitor. Consult your doctor about when to begin or discontinue these medications.

Also, avoid alcohol while taking this medication, as it could cause the drug to release too quickly and heighten side effects.

Be cautious if using medications to reduce stomach acid, like antacids or omeprazole, since they might affect certain brands of Methylphenidate ER. Check with your pharmacist regarding your specific brand.

It is crucial to inform your healthcare provider about all medications, supplements, and vitamins you are taking, as Methylphenidate ER may interact with them. Specifically, avoid taking dexmethylphenidate concurrently with methylphenidate.

Additionally, Methylphenidate ER might interfere with certain medical tests, such as brain scans for Parkinson's disease, leading to incorrect results. Ensure that all healthcare professionals involved in your care are aware of your use of this medication.

If you have questions or concerns about medication interactions, discuss them with your doctor or pharmacist to ensure safe use of Methylphenidate ER.