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Metafolbic is a dietary supplement combining L-methylfolate, methylcobalamin (vitamin B12), and acetylcysteine. While it offers health benefits, certain precautions are necessary to ensure its safe use.

Allergic Reactions: Individuals with known allergies to any of Metafolbic's components should avoid its use. Signs of an allergic reaction may include rash, itching, swelling, or difficulty breathing.

Anemia Considerations: Metafolbic is not suitable as a sole treatment for certain types of anemia, such as pernicious anemia, especially when accompanied by vitamin B12 deficiency. High doses of folic acid can mask symptoms of vitamin B12 deficiency, potentially leading to irreversible nerve damage if left untreated.

Kidney Stones: Those with a history of kidney stones should consult their healthcare provider before taking Metafolbic, as certain ingredients may influence stone formation.

Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Metafolbic with your doctor to ensure it aligns with your health needs.

Pediatric Use: Metafolbic is not recommended for children under 12 years of age.

Laboratory Tests: This supplement may affect certain lab test results. Inform your healthcare providers and lab personnel that you are taking Metafolbic to ensure accurate test interpretations.

Always consult with a healthcare professional before starting Metafolbic to determine its appropriateness for your individual health circumstances.

When taking Metafolbic, it's important to be aware of potential interactions with other medications and substances:

• Cholestyramine and Colestipol: These medications can interfere with the absorption of Metafolbic. If you're using either, consult your pharmacist on the best way to take them alongside Metafolbic.

• Levodopa: Metafolbic may reduce the effectiveness of levodopa, a medication used for Parkinson's disease. Inform your doctor if you're on levodopa therapy.

• Alcohol Consumption: Regular alcohol intake can lead to a deficiency in B-vitamins, including folate. If you consume alcohol frequently, discuss appropriate supplementation with your healthcare provider.

• Tobacco Use: Smoking may decrease the levels of levomefolate (a form of folate) in your body. Additional supplementation might be necessary; consult your doctor for guidance.

Always inform your healthcare provider about all medications, supplements, and lifestyle habits to ensure safe and effective use of Metafolbic.