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This document outlines essential safety and warning information for Metopirone (metyrapone). It is crucial to understand these risks and precautions to ensure safe use. If you have any concerns, please discuss them with your healthcare provider.

• Acute Adrenal Crisis: Metopirone reduces cortisol production, which can trigger an acute adrenal crisis, particularly if your adrenal glands are compromised. This condition is potentially life-threatening. Be vigilant for symptoms such as stomach pain, confusion, dizziness, weakness, headache, fever, nausea, vomiting, rapid heartbeat, or rapid breathing. Should these occur, seek immediate medical attention. Risk group: Those with adrenal gland dysfunction.

• Overdose: Exceeding the prescribed dosage of Metopirone can lead to an overdose, which is particularly hazardous if you are also taking insulin or oral medications for diabetes. Symptoms of overdose include nausea, vomiting, diarrhea, anxiety, confusion, weakness, fainting, irregular heartbeat, and low blood pressure. Immediate medical assistance is necessary if these symptoms present. Always adhere strictly to the dosage instructions provided by your healthcare professional. Risk factors: Usage of insulin or oral diabetes medications.

• Contraindications: Metopirone should not be used if you have adrenal gland disorders, as it may pose significant health risks. Prior consultation with your healthcare provider is necessary if this applies to you.

These guidelines are intended to ensure safe and effective usage of Metopirone. Always follow the advice of your healthcare provider and report any adverse symptoms promptly.

When taking this medication, you might encounter some common side effects such as nausea, upset stomach, headache, dizziness, drowsiness, tiredness, vomiting, and stomach pain or discomfort. These effects are generally mild and often not a cause for concern. However, if they persist or worsen, it is advisable to consult your healthcare provider for guidance.

There are also some rarer side effects to be aware of, such as a rash or extreme sleepiness. Additionally, a decrease in white blood cell count may occur, which can sometimes present with symptoms such as fever and cough. Although these side effects are less common, it is important to inform your healthcare provider if they occur.

Serious side effects are uncommon but require immediate medical attention if they do occur. These include symptoms of an acute adrenal crisis, such as severe stomach pain, confusion, dizziness, weakness, headache, fever, low blood pressure, nausea, vomiting, a fast heart rate, and rapid breathing. A very serious allergic reaction to the medication is also rare, but medical help should be sought immediately if you notice symptoms like rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. While this is not an exhaustive list of potential side effects, it covers the most significant ones to be aware of.