Mifepristone is a limited distribution medication.

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generic Mifeprex, Korlym

Mifepristone, also known as Mifeprex or RU 486, is a prescription medication used to medically terminate an early pregnancy, typically within the first 10 weeks (up to 70 days from the start of the last menstrual period). In some instances, it may be used up to 11 weeks. This medication works by blocking progesterone, a hormone essential for maintaining a pregnancy. When combined with another medicine, misoprostol (Cytotec), it effectively halts the progression of the pregnancy. Mifepristone is not suitable for use in cases of ectopic pregnancies, as it cannot terminate such pregnancies and may lead to severe complications, including rupture and heavy bleeding. Common side effects include nausea, cramps, and vaginal bleeding, which should be monitored closely by a healthcare provider to ensure the pregnancy has been fully terminated and to manage any severe symptoms. Always consult with a healthcare professional before starting this treatment.

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Mifepristone Warnings Mifepristone Side Effects Mifepristone Interactions FAQs

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200MG, Mifepristone (30 Tablets)

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CVS

$1421.19

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Walgreens

$466.00

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Rite Aid

$1261.01

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Walmart

$1435.01

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CVS

$1421.19

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019876

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Mifepristone dosage forms

The average cost for 30 Tablets of Mifepristone (generic Mifeprex, Korlym) at 200MG is $466 with a free coupon. This is 12.92% off the average retail price of $3606.19

Dosage	Quantity	Price from	Per unit
200MG	30 Tablets	$466	$15.53
300MG	30 Tablets	$5695.39	$189.85

Mifepristone Warnings

This information outlines important safety considerations and precautions for the use of mifepristone, commonly prescribed for medical abortion. Please read this carefully and consult your healthcare provider if you have any questions or concerns.

Potential Risks: Rarely, serious medical issues such as infections and excessive bleeding may occur. These can, in some cases, be life-threatening. It is crucial to consult your doctor and familiarize yourself with the Medication Guide and the Patient Agreement if you are in the United States. This medication is subject to the REMS Program requirements, which you must agree to and follow. If you reside in another country, consult your healthcare provider for specific regulations.
Signs of Serious Infection: Seek immediate medical assistance if you experience symptoms like severe abdominal pain, fainting, a rapid heartbeat, or a fever exceeding 100.4ºF lasting more than four hours. These symptoms may indicate a severe infection, particularly if they arise more than 24 hours after taking misoprostol. Even in the absence of a fever, symptoms such as nausea, vomiting, diarrhea, or weakness require urgent medical attention.
Vaginal Bleeding: While vaginal bleeding is expected during a medical abortion, it should be monitored closely. If you experience excessive bleeding—defined as soaking through two thick, full-size sanitary pads per hour for two consecutive hours—seek emergency care immediately. This may signal an incomplete abortion requiring prompt medical intervention.
Contraindications: Do not use this medication if you have a confirmed or suspected ectopic pregnancy, undiagnosed adnexal mass, adrenal gland failure, or if you are on long-term corticosteroids. Additionally, those with allergies to prostaglandins, blood disorders, or who are taking blood thinners should avoid this medication. If you have an intrauterine device (IUD), it must be removed before taking mifepristone.
Emergency Instructions: Your healthcare provider should provide clear instructions on who to contact and what actions to take in the event of an emergency, such as severe bleeding or infection. Always carry the Medication Guide if you need to seek emergency care or consult another healthcare professional.

This safety information is crucial for ensuring your well-being during the use of mifepristone. Always communicate with your healthcare provider for personalized advice and guidance.

Mifepristone Side Effects

Common side effects:

nausea
vomiting
diarrhea
dizziness
weakness
headache
fever or chills

Less common but important to monitor:

bleeding
cramping

Serious side effects:

persistent fever of 100.4°F (38°C) or higher
severe abdominal pain
fainting
rapid heartbeat
symptoms of a serious allergic reaction (rash, severe dizziness, swelling, difficulty breathing)
nausea, vomiting, or diarrhea continuing for more than 24 hours after taking the second medication (misoprostol)

Mifepristone Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Bepridil
Cisapride
Cyclosporine
Dihydroergotamine
Dronedarone
Ergotamine
Fentanyl
Fluconazole
Ketoconazole
Lovastatin
Mesoridazine
Pimozide
Piperaquine
Posaconazole
Quinidine
Saquinavir
Simvastatin
Sirolimus
Sparfloxacin
Tacrolimus
Terfenadine
Thioridazine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Alfentanil
Alprazolam
Amiodarone
Amisulpride
Anagrelide
Apomorphine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Azithromycin
Benzhydrocodone
Boceprevir
Buprenorphine
Buserelin
Carbamazepine
Ceritinib
Chloroquine
Chlorpromazine
Cilostazol
Ciprofloxacin
Citalopram
Clarithromycin
Clofazimine
Clomipramine
Clozapine
Cobicistat
Codeine
Colchicine
Conivaptan
Crizotinib
Dabrafenib
Dasabuvir
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Digoxin
Dihydrocodeine
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxorubicin
Doxorubicin Hydrochloride Liposome
Droperidol
Efavirenz
Encorafenib
Entrectinib
Erythromycin
Escitalopram
Fingolimod
Flecainide
Fluoxetine
Formoterol
Foscarnet
Fosphenytoin
Fostemsavir
Gemifloxacin
Glasdegib
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Histrelin
Hydrocodone
Hydroxychloroquine
Hydroxyzine
Ibutilide
Idelalisib
Ifosfamide
Iloperidone
Imipramine
Indinavir
Inotuzumab Ozogamicin
Itraconazole
Ivabradine
Ivosidenib
Lapatinib
Lefamulin
Lemborexant
Lenvatinib
Levofloxacin
Lofexidine
Lopinavir
Lumefantrine
Macimorelin
Mefloquine
Meperidine
Methadone
Metronidazole
Mirtazapine
Moxifloxacin
Nafarelin
Naloxegol
Nefazodone
Nelfinavir
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Olaparib
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Oxycodone
Ozanimod
Paliperidone
Panobinostat
Pasireotide
Pazopanib
Pentazocine
Phenobarbital
Phenytoin
Pimavanserin
Pitolisant
Ponesimod
Procainamide
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinine
Ranolazine
Ribociclib
Rifabutin
Rifampin
Rifapentine
Ritonavir
Selpercatinib
Sertraline
Sevoflurane
Simeprevir
Siponimod
Sodium Phosphate
Solifenacin
Sorafenib
Sotalol
St John's Wort
Sufentanil
Sulpiride
Sunitinib
Telaprevir
Telavancin
Telithromycin
Tetrabenazine
Toremifene
Tramadol
Trazodone
Triclabendazole
Trifluoperazine
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vemurafenib
Vinflunine
Voclosporin
Voriconazole
Ziprasidone
Zuclopenthixol

Interactions with low risk that usually do not require a change in therapy:

Fluvastatin

Mifepristone FAQs

Can mifepristone alone end pregnancy?

Mifepristone alone is not typically sufficient to end a pregnancy effectively. It is usually used in combination with another medication, misoprostol, to increase the efficacy of the medical abortion process. Mifepristone works by blocking the hormone progesterone, which is necessary for pregnancy to continue, while misoprostol induces contractions to expel the pregnancy. It is important for individuals to follow the guidance of a healthcare professional when using these medications.

Will I bleed after taking mifepristone?

It is common for individuals to experience bleeding after taking mifepristone, especially when it is followed by misoprostol as part of a medical abortion process. The bleeding can vary in intensity and duration, and it is important to follow up with a healthcare provider to ensure the process is complete and to address any concerns.

How do I know that mifepristone is working?

The effectiveness of mifepristone is typically assessed by the occurrence of bleeding and cramping, which usually indicates that the medication is working. However, it is important to follow up with a healthcare provider to confirm that the process is complete. This may involve an ultrasound or a blood test to measure hormone levels. If there are any concerns or if the expected symptoms do not occur, it is crucial to contact a healthcare professional for further evaluation.

Does mifepristone alone cause birth defects?

Mifepristone alone is not known to cause birth defects. However, it is important to note that mifepristone is typically used in combination with another medication, misoprostol, for medical termination of pregnancy. If the pregnancy continues after taking mifepristone, there is a potential risk of birth defects, particularly if misoprostol is also taken. It is crucial to follow medical guidance and complete the treatment as prescribed.

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