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Here is essential safety and warning information for those considering or prescribed Motofen (difenoxin / atropine). It is important to understand the potential risks associated with this medication and adhere to the guidelines provided. Consult your healthcare provider if you have any concerns.

• Overdose and Atropine Poisoning: Excessive use of Motofen can lead to overdose, resulting in severe health issues such as respiratory problems, brain damage, coma, or death. This risk is particularly high in children under 2 years of age. Those advised to avoid anticholinergic drugs should not use this medication, as it can lead to atropine poisoning, especially in individuals with Down's syndrome. Even recommended doses can cause atropine poisoning in children.

• Dehydration and Electrolyte Imbalance: Diarrhea can cause significant fluid and electrolyte loss, leading to dehydration, which may become life-threatening if untreated. While taking Motofen, ensure adequate hydration by drinking plenty of fluids. Dehydration poses a significant risk, particularly in children, and could exacerbate adverse effects. Inform your healthcare provider if you are taking other medications that affect gastrointestinal motility, as this could increase dehydration risk.

• Inflammation of Colon and Intestines: If you have ulcerative colitis, use Motofen with caution. Severe cases may develop toxic megacolon, a potentially life-threatening condition. Notify your healthcare provider immediately if you experience symptoms such as abdominal pain, swelling, bloody diarrhea, fever, rapid heartbeat, or confusion.

• Liver and Kidney Damage: Individuals with liver or kidney disease should consult their healthcare provider before using Motofen, as it can worsen liver damage and lead to brain impairment. If you notice confusion or difficulty in thinking, seek medical attention promptly.

Contraindications

• Do not use Motofen if you have diarrhea caused by antibiotics or bacterial infections like C. diff, E. coli, Salmonella, or Shigella.
• Avoid this medication if you have a history of jaundice.
• It is contraindicated for children under the age of 2.

Always discuss with your healthcare provider before starting or stopping any medication to ensure it is safe for you, especially if you have underlying health conditions or are taking other substances.

When taking this medication, you might experience some common side effects such as nausea, dizziness, drowsiness, headache, dry mouth, and tiredness. These effects are generally mild and often resolve on their own. However, if they persist or become bothersome, it is advisable to consult with your healthcare provider.

In addition, some individuals may experience other side effects like vomiting, stomach upset, constipation, nervousness, insomnia, confusion, burning eyes, or blurry vision. While these may be uncomfortable, they are typically not serious. Should any of these effects become severe, seeking advice from a healthcare professional is recommended.

There are also rare but serious side effects that demand immediate medical attention. These include severe allergic reactions characterized by rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, and trouble breathing. Additionally, be alert for signs such as severe nausea, vomiting, abdominal pain or swelling, mood changes like depression or confusion, restlessness, numbness or tingling in the limbs, or significant changes in vision, such as seeing rainbows around lights.

In the event of an overdose, symptoms might include dry or flushed skin, significant tiredness, muscle weakness, breathing difficulties, slowed breathing, small pupils, uncontrolled eye movements, or a rapid heart rate. If any of these symptoms occur, immediate medical care is necessary. Always remember that while side effects are possible, many people do not experience severe issues with this medication.

When taking Motofen (difenoxin/atropine), it is important to inform your doctor and pharmacist about all other medications or supplements you are using, including prescriptions, over-the-counter drugs, vitamins, and herbal products. Some drugs should not be taken with Motofen, such as ambenonium, nalmefene, naltrexone, and potassium products, as these can lead to adverse interactions.

Furthermore, several medications might usually be avoided with Motofen unless specifically advised by your doctor. These include various opioids (like codeine and hydrocodone), benzodiazepines (such as alprazolam and lorazepam), and other central nervous system depressants that can increase drowsiness. It is important to pay attention to product labels, particularly on allergy or cough-and-cold medications, to avoid additional ingredients that may cause drowsiness.

In some cases, combining Motofen with other medications might be necessary, but your doctor may need to adjust dosages or monitor you closely for side effects. Always follow your healthcare provider's guidance to ensure safe and effective treatment.