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Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that can alleviate pain and reduce inflammation. However, it is important to be aware of potential risks and necessary precautions while using this medication. Review the following safety information and consult a healthcare professional with any concerns:

• Cardiovascular Risks: Ibuprofen may increase the risk of heart attack or stroke. This risk is higher with long-term use, higher doses, and in individuals with existing heart issues. Avoid ibuprofen if you have recently undergone or are planning heart surgery. Seek immediate medical help if you experience chest pain, shortness of breath, or sudden weakness or numbness.

• Gastrointestinal Risks: The medication can cause serious stomach issues, including bleeding and ulcers, potentially without warning. This risk is elevated in older adults, those with a history of stomach problems, or those taking other medications like blood thinners. If you experience severe stomach pain, black or bloody stools, or vomit resembling coffee grounds, contact a healthcare provider immediately.

• Hypertension and Heart Failure: Ibuprofen may lead to fluid retention, increasing the risk of high blood pressure or heart failure. Discuss your medical history with your healthcare provider, especially if you have heart issues or are on blood pressure medications. Unexplained fainting, chest pain during physical activity, or irregular heartbeat should be reported to your provider.

• Kidney Concerns: The drug can impair kidney function, particularly in older adults or those with pre-existing conditions like diabetes. Regular kidney function tests may be necessary. Notify your provider if you notice changes in urination, fatigue, dry skin, or muscle cramps.

• Liver Effects: While rare, ibuprofen can cause severe liver damage. Promptly seek medical attention if you observe symptoms like abdominal swelling, jaundice, dark urine, or confusion.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur. Inform your provider of any allergies to aspirin or NSAIDs. If you experience hives, difficulty breathing, or swelling of the face, seek emergency care.

• Pregnancy Warnings: Ibuprofen can harm an unborn baby, particularly in the later stages of pregnancy. Discuss alternative pain relief options with your healthcare provider if you are pregnant.

• Phenylketonuria (PKU) Caution: Chewable ibuprofen tablets contain phenylalanine, which can be harmful to those with PKU. Consult a healthcare provider for suitable alternatives.

• Contraindications: Do not use ibuprofen if you have a history of asthma or allergic reactions to NSAIDs, or if you are undergoing coronary artery bypass graft surgery.

Always discuss your full medical history and current medications with your healthcare provider before starting ibuprofen to ensure it is safe for you.

When taking this medication, some individuals may experience mild side effects such as nausea, upset stomach, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These effects are generally not serious, but if they persist or worsen, consult your healthcare provider. Monitoring your blood pressure is advisable, as this medication can cause an increase, and you should inform your doctor if high readings are observed.

Less common side effects include low appetite, stomach pain, heartburn, rash, ringing in the ears, and vision changes. If you experience any of these, especially if they become bothersome, contact your healthcare provider for advice.

There are rare but serious side effects that require immediate medical attention. These include symptoms of liver damage, like persistent nausea, vomiting, loss of appetite, dark urine, stomach pain, and yellowing of the skin or eyes. Additionally, be aware of signs of heart failure, such as swelling of the ankles or feet, unusual tiredness, and sudden weight gain, as well as symptoms of a heart attack or stroke. Kidney problems may manifest as changes in urination, muscle cramps, and unusual fatigue.

Serious allergic reactions are rare but can occur. Seek urgent medical help if you notice symptoms like fever, swollen lymph nodes, rash, severe dizziness, or trouble breathing. Always report any other unexpected effects to your healthcare provider.

When taking ibuprofen, it's important to be aware of potential interactions with other medications:

1. Avoid Combining with Certain Medications: Ibuprofen should not be used with ketorolac, as this combination is not recommended.

2. Caution Advised with Certain Medications: There are medications that usually should not be taken with ibuprofen, but may be used together under specific circumstances. Your doctor might adjust dosages if both are necessary. These include blood thinners like warfarin, anticoagulants such as dabigatran, and various anti-inflammatory drugs like aspirin, celecoxib, or naproxen.

3. Increased Bleeding Risk: Ibuprofen can increase bleeding risk when combined with drugs that have similar effects, such as clopidogrel and other anti-platelet medications, as well as blood thinners like enoxaparin.

4. Similar Medication Caution: Many over-the-counter products, including some pain relievers and fever reducers, contain ingredients similar to ibuprofen, such as aspirin and NSAIDs. Combining these can increase the likelihood of side effects.

5. Special Considerations for Aspirin Users: If you are taking low-dose aspirin to prevent heart attacks or strokes, continue as advised by your doctor. However, ibuprofen may reduce aspirin's effectiveness in preventing heart attacks or strokes. Consult your doctor about alternatives like acetaminophen for pain or fever relief. If you need to take ibuprofen, it's suggested to take it either 8 hours before or 2 hours after your aspirin dose.

6. Interactions with Heart and Blood Pressure Medications: Ibuprofen can interact with various heart and blood pressure medications, including ACE inhibitors (like lisinopril), angiotensin II receptor blockers (like losartan), and beta-blockers (like metoprolol). Your doctor may need to adjust dosages when these medications are used together.

Always inform your healthcare provider about all medications and supplements you are taking to manage the risk of interactions effectively.