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When using Muse (alprostadil), it is crucial to be aware of the safety warnings and contraindications to ensure its safe use. Discuss any concerns with your healthcare provider.

• Low Blood Pressure Risk: Muse (alprostadil) may cause a drop in blood pressure, leading to symptoms like dizziness, lightheadedness, blurred vision, or fainting, typically occurring within an hour of administration. To minimize these effects, the lowest effective dose will be prescribed, with gradual dose adjustments under medical supervision. Refrain from driving or engaging in activities requiring alertness if dizziness or fainting occurs.

• Minor Bleeding or Spotting: The medication may cause minor bleeding or spotting from the urethra. This risk is heightened if you are on blood thinners or have a bleeding disorder. Discuss the potential risks and benefits with your healthcare provider if you are prone to bleeding.

• Prolonged Erection (Priapism): Rarely, Muse (alprostadil) can lead to a prolonged, painful erection lasting more than four hours. Seek immediate medical attention if this condition occurs, as it can cause permanent damage if untreated. Dosage adjustments or discontinuation may be necessary.

• Medication Interactions: Concurrent use with blood pressure medications can increase the risk of low blood pressure, leading to dizziness or fainting. Inform your healthcare provider of any blood pressure medications to determine the safety of using Muse (alprostadil).

Contraindications: Muse (alprostadil) should not be used under the following conditions due to potential serious health risks. Consult your healthcare provider if any of these apply to you:

• Abnormal penile anatomy
• Current or frequent urinary tract infections
• Disorders causing prolonged erections (e.g., sickle cell anemia, leukemia, multiple myeloma)
• Engaging in sexual intercourse with a pregnant partner without a condom
• If advised against sexual activity
• Inflammation or infection in the penis

Ensure to follow your healthcare provider's guidance and report any adverse effects promptly for safe and effective use of Muse (alprostadil).

When taking this medication, you may experience some common side effects that are usually mild. These include pain in the penis, minor bleeding or spotting from the urethra, pain in the testicles, and a burning sensation in the urethra. Female partners might experience vaginal burning or itching, which could be eased with a water-based lubricant. Though these effects are generally not serious, it's important to consult a healthcare provider if they persist or worsen.

Some individuals might also report dizziness, fainting, flu-like symptoms, headaches, accidental injuries, back pain, pelvic pain, or a runny nose. While these are less common, it's advisable to contact a healthcare provider if they occur, particularly if they become severe.

There are serious side effects that are rare but require immediate medical attention. One such effect is a prolonged erection lasting more than four hours, which can lead to permanent damage if not treated promptly. Additionally, severe allergic reactions, though very rare, require urgent care. Symptoms can include rash, severe dizziness, trouble breathing, and swelling, particularly of the face, tongue, or throat. Always stay vigilant and report any unusual symptoms to your healthcare provider.