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When using Muse (alprostadil), it is crucial to be aware of the safety warnings and contraindications to ensure its safe use. Discuss any concerns with your healthcare provider.

• Low Blood Pressure Risk: Muse (alprostadil) may cause a drop in blood pressure, leading to symptoms like dizziness, lightheadedness, blurred vision, or fainting, typically occurring within an hour of administration. To minimize these effects, the lowest effective dose will be prescribed, with gradual dose adjustments under medical supervision. Refrain from driving or engaging in activities requiring alertness if dizziness or fainting occurs.

• Minor Bleeding or Spotting: The medication may cause minor bleeding or spotting from the urethra. This risk is heightened if you are on blood thinners or have a bleeding disorder. Discuss the potential risks and benefits with your healthcare provider if you are prone to bleeding.

• Prolonged Erection (Priapism): Rarely, Muse (alprostadil) can lead to a prolonged, painful erection lasting more than four hours. Seek immediate medical attention if this condition occurs, as it can cause permanent damage if untreated. Dosage adjustments or discontinuation may be necessary.

• Medication Interactions: Concurrent use with blood pressure medications can increase the risk of low blood pressure, leading to dizziness or fainting. Inform your healthcare provider of any blood pressure medications to determine the safety of using Muse (alprostadil).

Contraindications: Muse (alprostadil) should not be used under the following conditions due to potential serious health risks. Consult your healthcare provider if any of these apply to you:

• Abnormal penile anatomy
• Current or frequent urinary tract infections
• Disorders causing prolonged erections (e.g., sickle cell anemia, leukemia, multiple myeloma)
• Engaging in sexual intercourse with a pregnant partner without a condom
• If advised against sexual activity
• Inflammation or infection in the penis

Ensure to follow your healthcare provider's guidance and report any adverse effects promptly for safe and effective use of Muse (alprostadil).

Muse, a medication containing Alprostadil, was used to treat erectile dysfunction by delivering the drug directly into the urethra. While systemic drug interactions with Muse were considered unlikely due to minimal absorption into the bloodstream, certain considerations were important:

• Combination with Other Erectile Dysfunction Treatments: Using Muse alongside other erectile dysfunction medications, such as Sildenafil (Viagra) or Tadalafil (Cialis), was generally not recommended. Combining these treatments could increase the risk of side effects like dizziness, lightheadedness, fainting, flushing, headache, or a rapid heart rate. Patients were advised to consult their healthcare provider before combining these medications.

• Use with Antihypertensive Medications: Although formal studies were not conducted, it was advised that caution be used in the administration of Muse to individuals on antihypertensive medications, as the combination could potentially increase the risk of low blood pressure.

• Alcohol Consumption: While Muse itself had minimal systemic absorption, combining it with alcohol could potentially increase the risk of side effects such as dizziness or fainting. Patients were advised to limit alcohol intake when using Muse.

It's important to note that Muse was discontinued in the United States in June 2024 and is no longer available. Patients who were using Muse should consult their healthcare provider for alternative treatments for erectile dysfunction.